Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine.
J H Boatright, N M Rubim, P M Iuvone
https://pubmed.ncbi.nlm.nih.gov/7947393Actively Recruiting
Phase Not Applicable
Age: 18Years - 64Years
All Genders
ID07517484
Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia
Led by Peking University People's Hospital · Updated on 2026-05-29
66
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial investigates how different light conditions affect sedation depth during general anesthesia. The study aims to understand whether light exposure changes the amount of anesthetic drugs needed and the mechanisms behind this effect. Participants are adults aged 18 to 65 years with certain health status and body mass index ranges. Participants are randomly assigned to one of two groups: the light-shielded group or the non-light-shielded group. Those in the light-shielded group wear an opaque eye mask starting 30 minutes before anesthesia and continue wearing it until sedative medications are stopped. The other group receives no intervention related to light exposure. Throughout the surgery, researchers will record induction drug doses, induction time, total anesthetic dosage during surgery, and emergence time from anesthesia. These measurements help assess how light exposure influences anesthesia. The study runs until June 2026, with follow-up and monitoring during the perioperative period.
CONDITIONS
Brief Title
Light and Anesthesia
Who Can Participate
Age: 18Years - 64Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years, regardless of gender
- ASA physical status I or II
- Body mass index between 18.5 and 28
- Signed written informed consent
You will not qualify if you...
- Blindness or history of photosensitivity disorders
- Need for medication for sleep or history of sleep disorders
- Presence of neurological diseases
- Pregnancy
- Severe liver or kidney dysfunction
- History of anesthetic drug abuse or alcohol abuse
- History of adverse anesthesia events such as difficult airway or allergy to anesthetic agents
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Implementation
Duration - Perioperative period
Participants in the light-shielded group wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the sedative medications are stopped.
1 perioperative visit (in-person)
Trial Site Locations
Total: 1 location
1
Peking University People's Hospital
Beijing, China, 100044
Actively Recruiting
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Research Team
Y
Yi Feng, Ph.D
X
Xiaoyan Li, Ph.D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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Diurnal variations in recovery times after general anaesthesia in children.
J Szolnoki, D M Polaner, T Eckle
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Jiang-Hua Shen, Min Ye, Qian Chen...
https://pubmed.ncbi.nlm.nih.gov/34488646Circadian differences in emergence from volatile anaesthesia in mice: involvement of the locus coeruleus noradrenergic system.
Dan Wang, Yujie Huang, Xinxin Wang...
https://pubmed.ncbi.nlm.nih.gov/32807382Effect of daily light exposure on sleep in polar regions: A meta-analysis.
Yingqi Shao, Yao Li, Nan Wang...
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Masao Ishizawa, Takuya Uchiumi, Miki Takahata...
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Yvan Touitou, Alain Reinberg, David Touitou
https://pubmed.ncbi.nlm.nih.gov/28214594Exposure to Short Wavelength-Enriched White Light and Exercise Improves Alertness and Performance in Operational NASA Flight Controllers Working Overnight Shifts.
Laura K Barger, Jason P Sullivan, Steven W Lockley...
https://pubmed.ncbi.nlm.nih.gov/33065729Bright light during nighttime: effects on the circadian regulation of alertness and performance.
A Daurat, J Foret, O Benoit...
https://pubmed.ncbi.nlm.nih.gov/11025337Circadian rhythms and mood disorders: Time to see the light.
Hannah K Dollish, Mariya Tsyglakova, Colleen A McClung
https://pubmed.ncbi.nlm.nih.gov/37858331