Beni Suef

Researchers are evaluating the performance, feasibility, and safety of emergency spacers compared to traditional spacers for delivering aerosolized drugs using pressurized metered-dose inhalers (pMDI) in young children and adults with mild to moderate asthma. The study focuses on measuring the total emitted drug dose, lung and systemic bioavailability, lung function, and safety after inhalation with different spacers. This Phase 4 trial addresses concerns about poor inhaler technique and electrostatic charges affecting drug delivery, especially in emergency and resource-limited settings. Participants will inhale salbutamol using pMDI alone or connected to various spacers, including traditional antistatic devices like Able and Aerochamber plus, and emergency disposable spacers made from materials like plastic juice cups and paper sheets. The study involves in-vitro testing of drug delivery and particle size, in-vivo use in 120 patients divided into groups based on spacer type, and ex-vivo collection of inhaled drug using filters. Lung function tests and heart rate monitoring will be performed to assess safety. During the study, participants will perform lung function tests before and after inhalation, provide urine samples 30 minutes and 24 hours post-dose for drug analysis, and have heart rate measured with a pulse oximeter. Measurements include total emitted dose, particle size characteristics, lung and systemic drug availability, and lung function changes. The study will last from October 2024 to October 2025, with evaluations designed to ensure the safety and effectiveness of different spacer types in delivering aerosolized medication.

Heart failure is a condition where the heart cannot pump enough blood to meet the body's needs, leading to symptoms like reduced exercise ability and shortness of breath. Many patients with heart failure also experience weakness in the muscles used for breathing, which worsens their physical activity and overall health. This research evaluates whether combining inspiratory muscle training with functional electrical stimulation of the lower limbs can improve heart function and physical capacity in patients hospitalized with worsening heart failure. The study will enroll 135 patients with decompensated heart failure, divided into three groups. One group will receive standard medical care plus inspiratory muscle training and electrical stimulation of their leg muscles. The second group will receive medical care plus inspiratory muscle training only. The third group will have standard medical care alone. Inspiratory muscle training involves using a device that provides resistance during breathing exercises for 30 minutes per session, 4-5 times a week, over four weeks. Functional electrical stimulation will target leg muscles using surface electrodes for about 45 minutes per session. Participants will be monitored during hospitalization and for four weeks of treatment. Researchers will measure heart function, breathing muscle strength, and exercise ability with a six-minute walk test at the start and after four weeks. They will also assess breathlessness, quality of life, heart rate, oxygen levels, hand grip strength, and maximum exhalation pressure. This study aims to determine if combining these therapies can offer better rehabilitation outcomes for patients with severe heart failure.

Researchers are evaluating the efficiency of direct 3D printed aligners in moving the crowns of upper and lower front teeth in adults with spacing between teeth. The study compares the actual tooth movements achieved during treatment with the predicted movements planned before treatment. It involves adult patients aged 18 to 45 years with specific dental conditions including spacing and certain types of malocclusion. The study involves 23 patients who will receive direct 3D printed aligners after intraoral scans of their upper and lower teeth. Patients will use these aligners, changing each set every 10 days according to instructions, with aligners warmed before use to help fit and comfort. At the end of treatment, another intraoral scan will be taken to capture the actual dental changes. The predicted and actual tooth movements will be digitally compared using 3D models and software. Throughout the study, patients will undergo intraoral scanning before and after treatment. The digital models will be superimposed to measure the crown movements of the incisors in millimeters. Data will be collected and analyzed statistically to assess the aligners' performance over 9 to 12 months. This includes careful monitoring of tooth positions and treatment progress to evaluate the effectiveness of the 3D printed aligners in correcting spacing issues.

Researchers are studying how adding deep breathing exercises to core stability workouts may help people with ankylosing spondylitis (AS), a condition that causes pain, stiffness, and posture problems affecting breathing. The study explores whether this combined exercise approach improves respiratory function and overall physical fitness, building on known benefits of exercise for AS but addressing a gap about the best types and doses of exercises. Participants will perform core stability exercises, with some also doing deep breathing exercises. The study compares these approaches to see which better supports strength, spinal mobility, posture, and lung function. Medical treatments like NSAIDs, DMARDs, and biologics continue as usual, while physical therapy focuses on maintaining mobility and reducing pain. Throughout the study, participants will be monitored and tested for respiratory function after 4 to 6 weeks of treatment. Researchers will assess posture, mobility, and physical fitness to measure improvements. The study includes adults aged 20 to 45 with stable AS who have not recently changed medications or joined other rehab programs, ensuring careful evaluation of these exercise interventions.

Residual renal stone fragments are a common problem after percutaneous nephrolithotomy (PCNL), occurring in 10% to 30% of patients. These leftover stones can lead to new stone formation, infections, or blockages, often requiring further treatment. This study is designed to compare the best timing for extracorporeal shock wave lithotripsy (ESWL), a non-invasive treatment, after PCNL to improve stone clearance and reduce complications. Participants with residual kidney stones 15 mm or smaller after PCNL will be randomly assigned to one of two groups. The first group will receive ESWL early, within 7 to 14 days after PCNL, while the second group will have delayed ESWL after 3 to 4 weeks. All patients will be treated with the same lithotripter using standardized energy and shock settings, with up to three ESWL sessions allowed per patient. Sedation or pain relief will be provided as needed during the treatments. Throughout the study, patients will be monitored clinically and through imaging tests like ultrasound or CT scans to evaluate stone clearance, defined as no residual fragments larger than 2 mm. The main outcome measured is the stone-free rate three months after ESWL. Additional assessments include complications such as bleeding or infection, pain levels, kidney function tests, and the need for further procedures. This research aims to guide doctors on the ideal timing of ESWL after PCNL to improve patient outcomes safely.

This research aims to evaluate the effect of muscle energy technique on children aged 6 to 12 years with post-traumatic elbow stiffness following fractures such as distal end extra-articular humerus fractures and proximal radius ulna fractures. Elbow fractures are common in pediatric patients and can lead to pain, limited range of motion, and functional disability. The study focuses on how this manual therapy might influence pain levels, functional ability, and elbow movement in these children. The study compares the muscle energy technique (MET), a manual therapy using gentle muscle contractions to relax and lengthen muscles, against conventional treatments including hot packs, range of motion exercises, stretching, and strengthening exercises. MET involves active participation by the patient and is based on muscle inhibition concepts. Treatments are applied during a 4-week period to address stiffness and improve joint function. Participants will undergo regular assessments to measure pain, disability, and range of motion over the 4 weeks of treatment. Evaluations include physical examinations to monitor improvements and detect any complications. The study tracks how well the techniques improve elbow movement and reduce stiffness, aiming to understand the benefits of MET compared to standard care in children recovering from elbow fractures.

Researchers are studying the effect of different vasodilators, specifically pentoxifylline, on women with unexplained infertility undergoing IVF. This phase 3 clinical trial includes women aged 18 to 43 years who have good quality day five frozen embryos. The purpose is to evaluate whether adding pentoxifylline affects endometrial thickness and the outcomes of frozen embryo transfer. Participants are randomly assigned to one of two groups. The control group receives estradiol valerate pills starting at one pill three times daily, with possible dose increases based on ultrasound measurements of endometrial thickness. The treatment group receives pentoxifylline 400 mg once daily in addition to the estradiol valerate, starting the first day of the menstrual cycle until the day progesterone treatment begins. All participants undergo thorough history taking, laboratory hormone tests, and transvaginal ultrasound to measure endometrial thickness. Throughout the study, women are monitored with clinical exams, blood hormone tests including AMH, FSH, LH, estradiol, prolactin, and TSH, and ultrasound imaging. Researchers measure pregnancy outcomes one month after treatment to assess the effect of pentoxifylline. The study aims to provide clear data on how these treatments influence IVF success in women with unexplained infertility.

Benign vocal fold lesions often require microlaryngosurgery when conservative treatments do not work well, but recovery of voice after surgery can vary, with some patients experiencing ongoing voice problems or fatigue. This research aims to determine if injecting platelet-rich plasma (PRP) after surgery can improve voice recovery compared to surgery alone. The study compares voice outcomes between patients receiving PRP injections during surgery and those who receive standard care without PRP. Participants will have microlaryngoscopic surgery to remove benign vocal fold lesions under general anesthesia. One group receives an additional injection of 1.5 mL of autologous PRP into the vocal fold area near the surgical site right after surgery, while the other group receives conventional surgery without PRP. The PRP is prepared fresh from the patient's blood to help promote healing and improve voice quality. Both groups receive standard postoperative care. Participants will undergo voice assessments before surgery and again at 1 month and 3 months after surgery. These evaluations include auditory perceptual voice tests, videostroboscopy, acoustic and aerodynamic voice analyses, and patient questionnaires about voice fatigue and quality of life. Researchers will monitor voice changes over time and compare the effects of PRP injection on voice improvement and fatigue. All participants give written consent and complete standard preoperative tests, including medical history, ENT exam, lab tests, ECG, and anesthesia evaluation.

Researchers are evaluating how different vasodilators, specifically Tadalafil, affect women with unexplained infertility who are undergoing in vitro fertilization (IVF). This Phase 4 clinical trial focuses on women aged 18 to 43 years old who have good quality day five frozen embryos. The study aims to assess the impact of Tadalafil on endometrial thickness and the outcomes of frozen embryo transfer. Participants are randomly assigned into two groups. One group receives estradiol valerate 2 mg tablets, starting with one pill three times daily and possibly increasing to two pills three times daily based on endometrial thickness measured by vaginal ultrasound on day 9. The other group receives the same estradiol valerate treatment plus 5 mg of Tadalafil once daily from the first day of the cycle until starting progesterone treatment. Both groups undergo comprehensive history taking, physical examination, and laboratory tests including hormone levels and ultrasound imaging. During the study, participants are monitored through ultrasound and lab tests to track endometrial thickness and hormone levels. The main outcome measured is pregnancy status one month after treatment. Safety and effectiveness of the treatments are closely observed throughout the process, with informed consent and ethical approval obtained for the study.

This study evaluates the dental educational environment in Upper Egypt by using the Dundee Ready Education Environment Measure (DREEM) Questionnaire. It aims to understand how dental students perceive their learning environment at the Faculty of Dentistry, Beni-Suef University. Participants will complete the DREEM Questionnaire, which is designed to assess various aspects of the educational setting. The study is cross-sectional, meaning data is collected at one point in time to capture students' perceptions. Students involved in the study will fill out the questionnaire to provide feedback on their educational experience. The main outcome measured is how dental students perceive their educational environment over a period of three months. This feedback will help understand strengths and areas for improvement within the dental school environment.