Beni Suef

This research aims to compare emergency spacers to traditional spacers for delivering aerosolized drugs using pressurized metered-dose inhalers pMDIs in children and adults with asthma. It focuses on measuring the total drug dose emitted, the pharmacokinetics, lung and systemic bioavailability of aerosols, lung function after inhalation, and overall safety. The trial addresses issues with pMDI use and spacer materials, including electrostatic charge effects that impact drug delivery, especially important for young and elderly patients. Participants will inhale salbutamol through pMDI alone and with various traditional and emergency spacers, including devices made from everyday materials like plastic cups and paper sheets. The study includes in-vitro testing of emitted dose and particle size, in-vivo trials with 120 mild to moderate asthmatic patients assigned to 10 different spacer groups, and ex-vivo drug collection via filters at the mouth. Lung function tests, urine sampling, and heart rate monitoring will evaluate performance and safety. During the study, participants perform lung function tests before and 15 minutes after inhalation and provide urine samples 30 minutes and 24 hours post-dose to assess lung deposition and systemic absorption. Heart rate is monitored using a pulse oximeter. The study uses randomized assignment to various spacer types and measures outcomes such as total emitted dose, lung bioavailability, and heart rate over three to four months. Data analysis includes lung function parameters and safety monitoring, with participation lasting throughout the study period ending in February 2025.

Researchers are evaluating the effectiveness of biofeedback-assisted pelvic floor muscle training compared to conventional pelvic floor muscle training for treating sexual dysfunction caused by radiation in cervical cancer survivors. This study focuses on women who have undergone pelvic radiotherapy and experience complications such as pain during sex, reduced vaginal lubrication, and pelvic pain. It aims to provide high-quality evidence on whether adding biofeedback enhances pelvic floor rehabilitation outcomes in this specific cancer survivor group. Participants will be randomly assigned to one of two groups for 8 weeks. One group will receive supervised biofeedback-assisted pelvic floor muscle rehabilitation three times a week, including exercises with an intravaginal electromyographic probe providing real-time visual and auditory feedback. Sessions last 45-60 minutes and include muscle training, coordination, breathing, relaxation, stretching, and a home exercise program. The other group will receive supervised conventional pelvic floor muscle training without biofeedback but with similar exercise frequency, lifestyle advice, vaginal care, and a home program. During the study, participants will complete assessments at baseline, after 8 weeks, and at a 3-month follow-up. These include the Female Sexual Function Index to measure sexual function, pelvic floor electromyographic activity to assess muscle performance, and anxiety and depression scales. Researchers will monitor treatment progress and safety throughout. The total participation involves supervised sessions and home exercises over 8 weeks with follow-up evaluations to measure both subjective and objective treatment effects.

Heart failure is a common condition causing reduced exercise tolerance, shortness of breath, and poor quality of life. Many patients with heart failure develop inspiratory muscle weakness, which limits physical activity and worsens functional capacity. This study evaluates the effects of combining inspiratory muscle training IMT with functional electrical stimulation FES of the lower limbs in patients hospitalized with decompensated heart failure, aiming to improve cardiac and muscle function and exercise tolerance. Participants will be randomly assigned to one of three groups one receiving routine medical treatment plus both IMT and FES, another receiving routine medical treatment with IMT only, and a control group receiving routine medical treatment alone. Inspiratory muscle training involves using a device at 30% maximal inspiratory pressure for 30 minutes per session, 4-5 times weekly, for four weeks. Functional electrical stimulation is applied to leg muscles using surface electrodes with specific electrical settings for about 45 minutes per session. The interventions start during hospitalization and continue for four weeks. Participants will be assessed at baseline and after four weeks for maximum inspiratory pressure, dyspnea severity, quality of life, functional capacity via a 6-minute walk test, heart rate, oxygen saturation, hand grip strength, maximum expiratory pressure, and peak oxygen uptake. Length of hospital stay will also be recorded. The study involves close monitoring during hospitalization and follow-up assessments, aiming to clarify the role of combined IMT and FES in cardiac rehabilitation for this patient group.

Researchers are investigating ureteral stent-related symptoms in adults who need temporary stenting after unilateral ureteroscopy or retrograde intrarenal surgery for urinary stones. The study compares a newer ComfiJ ureteral stent with a conventional double-J ureteral stent to understand which stent causes fewer urinary symptoms and related issues. The trial is randomized and multicenter, focusing on patient comfort and quality of life after surgery. Participants will be randomly assigned during surgery to receive either a ComfiJ or conventional double-J ureteral stent if short-term postoperative stenting is needed. The stents are planned to remain in place for about 14 days before removal. The study uses a double-blind design where patients and outcome assessors do not know which stent was used, while surgeons are aware during insertion. Throughout the study, participants will complete the Arabic Ureteral Stent Symptom Questionnaire to assess urinary symptoms, along with pain scores and records of analgesic use, emergency visits, and complications. Researchers will also monitor stent migration, ease of insertion and removal, and patient satisfaction. The main outcome is the urinary symptoms score on day 14 before stent removal. Follow-up assessments occur up to postoperative day 14, and the study is scheduled to end in May 2027.

Researchers are evaluating the efficiency of direct 3D printed aligners in moving the crowns of upper and lower front teeth in adults with spacing issues during orthodontic space closure. This study focuses on comparing the actual tooth movements achieved with these aligners to the predicted movements planned before treatment. The trial will include adult patients aged 18 to 45 years with specific dental conditions, such as Angle Class I or mild Class II malocclusions and spacing between anterior teeth. Participants will receive direct 3D printed aligners designed after intraoral scans and 3D digital simulations of their teeth. Patients will be instructed to wear the aligners and to activate their shape memory by placing them in warm water before use. Aligners will be changed every 10 days throughout the treatment period, which lasts between 9 to 12 months. At the end of treatment, a new 3D scan will be taken to compare the actual tooth movements with the planned movements using digital superimposition techniques. During the study, patients will undergo intraoral scans before and after treatment, and 3D digital models will be created to measure crown movement in millimeters. These measurements will be analyzed statistically to determine the aligners effectiveness in achieving planned tooth movements. The study includes careful monitoring of dental health and malocclusion status, with no blinding or control group. The total duration of treatment and observation will be 9 to 12 months.

Researchers are evaluating the effects of deep breathing exercises combined with core stability exercises in treating patients with ankylosing spondylitis AS. AS can cause pain, reduced flexibility, and poor posture, which may negatively impact respiratory function. The study aims to see if adding deep breathing to core exercises improves respiratory health and physical function in people with this condition. Participants will be randomly assigned to one of two groups one group will perform deep breathing exercises along with core stability exercises designed to strengthen muscles and improve posture, while the other group will do core stability exercises alone. The deep breathing exercises focus on engaging the diaphragm to enhance lung function and relaxation. The study lasts 4 to 6 weeks, during which the effects of these exercise programs will be assessed. During the study, participants will be evaluated for respiratory function and functional exercise capacity after 4 to 6 weeks of treatment. The researchers will monitor improvements in lung efficiency, posture, strength, and overall physical fitness. The study is double-blinded and sponsored by Beni-Suef University, and participants will continue their usual medical treatments throughout the trial.

Researchers are evaluating two different HolmiumYAG laser techniques for treating children with a single bladder stone smaller than 3 cm. This trial compares the dusting method, which breaks the stone into fine particles, with the fragmentation method, which creates larger pieces that may be actively removed. The purpose is to find out which laser strategy results in shorter surgery time and better stone clearance in pediatric patients. Children will be randomly assigned to one of two groups for transurethral laser cystolithotripsy under general anesthesia. In the dusting group, low pulse energy and higher frequency settings 0.5-0.8 J and 10-15 Hz will be used to reduce stones to tiny fragments with minimal extraction. The fragmentation group will receive higher pulse energy and lower frequency settings 1.0 J and 6-10 Hz aiming to produce visible fragments sized 2-5 mm that can be removed. Procedures use a pediatric semi-rigid ureteroscope in the lithotomy position with a 550-micron laser fiber. Participants will be monitored during and after the procedure for total operation time, laser time, need for fragment extraction, and stone-free status via endoscopy and ultrasound. Follow-up visits at 1 week, 1 month, and 3 months will assess urinary symptoms, infections, catheter need, and hospital stay length. Safety will be evaluated by tracking complications such as mucosal injury, bleeding, hematuria, and dysuria. The study will last until May 2027.

Researchers are investigating the best timing for extracorporeal shock wave lithotripsy ESWL after percutaneous nephrolithotomy PCNL in patients with residual kidney stones measuring 15 mm or less. Residual stone fragments after PCNL are common and can lead to recurrent stones, infections, or blockages, often requiring further treatment. This randomized study aims to compare early ESWL within 7-14 days post-PCNL versus delayed ESWL after 3-4 weeks to find the optimal approach that balances stone clearance and complication risks. Participants are divided into two groups one receives ESWL treatment early, within 7-14 days after PCNL, and the other receives it later, after 3-4 weeks. Both groups use the same type of lithotripter and follow standardized treatment settings per European Association of Urology guidelines. Up to three ESWL sessions are allowed per patient with sedation or pain relief as needed. The study monitors patients clinically and with imaging to evaluate stone clearance. During the study, patients will undergo imaging tests such as ultrasound or non-contrast CT scans after ESWL to check for remaining stones. The main measure of success is the stone-free rate at 3 months. Secondary measures include rates of complications like bleeding or infection, pain levels, changes in kidney function, and the need for further procedures. Follow-up includes clinical and radiological assessments to guide treatment evaluation and patient safety over the course of the study.

Researchers are evaluating the protective effects of a combination of diosmin and hesperidin on kidney damage caused by platinum-based chemotherapy in cancer patients. This prospective randomized controlled study aims to understand whether this combination can reduce nephrotoxicity associated with platinum compounds used in cancer treatment. The study involves about 100 cancer patients between 18 and 75 years old who are receiving platinum compound chemotherapy. Participants are divided into two groups one group receives standard platinum compound chemotherapy alone, while the other group receives the same chemotherapy plus an oral dose of 450 mg diosmin and 50 mg hesperidin twice daily. The study is conducted from February 2025 to September 2025, with follow-up continuing for 6 months after treatment to assess kidney function. During the study, researchers will measure serum creatinine and blood urea levels six months after treatment to evaluate kidney health. They will also monitor hemoglobin levels as a secondary outcome. Participants will be closely observed for any side effects and adherence to the treatment protocol. The study is sponsored by Beni-Suef University and aims to provide insights into managing chemotherapy-induced kidney damage in cancer patients.

This research aims to compare two types of dental implantscompressive and conventionalplaced and loaded immediately after atraumatic tooth extraction. The study focuses on their effectiveness, bone resorption, and implant survival in patients needing implant treatment. It addresses the importance of oral health for chewing, speaking, appearance, and psychological well-being, especially after tooth loss caused by various conditions and systemic diseases. Participants will undergo immediate placement and loading of either compressive or conventional implants following atraumatic extraction of a badly destructed upper premolar tooth. The procedure includes preoperative cone beam imaging, local anesthesia, use of a piezoelectric device for extraction, implant placement into the alveolar bone, stability measurements using AnyCheck or periotest devices, and postoperative care. One week after surgery, a temporary crown will be placed to load the implant immediately. Throughout the 6-month study period, participants will have assessments of implant stability, pain levels, and measurements of crestal bone resorption and bone loss using periodontal probes and imaging. Follow-up includes postoperative imaging and monitoring of healing and implant function. The studys goal is to evaluate and compare how these implants perform in terms of bone preservation and patient comfort over time.