Shibin El Kom

Researchers are evaluating a fully digital, facially guided approach to full-mouth rehabilitation for adults with bite difficulties, smile dissatisfaction, and missing mandibular molars. This study focuses on patients with malocclusion and partial or complete tooth loss who need esthetic and functional dental restoration. The goal is to assess how integrated digital planning combining intraoral, facial, and CBCT scans can improve the precision and outcomes of dental rehabilitation. The treatment uses advanced digital planning to create a 3D virtual patient model that guides esthetic design, occlusion, and implant placement. Participants receive conservative anterior rehabilitation with lithium disilicate veneers, zirconia crowns, guided implant placement for missing molars, and temporary anchorage device-assisted intrusion of extruded molars. This fully digital workflow aims for precise restoration positioning, functional occlusion, and esthetic results. During the study, participants will undergo scans, treatments, and follow-up visits as part of the digital workflow. Researchers will measure implant stability 12 months after treatment to evaluate the success of the rehabilitation. Participants are expected to comply with treatment and follow-up protocols, and will be monitored for functional and esthetic outcomes using integrated digital data throughout the study period.

This research aims to evaluate the accuracy and speed of complete-arch implant scans using two different photogrammetry systems in adults with edentulous jaws who have implant-supported prostheses. The study compares a conventional intraoral photogrammetry device with a newer mobile-phone-based photogrammetry system to see if the mobile-phone method can provide similar accuracy while being more efficient. This comparison is important for improving digital impression methods in dental implant care. Participants will have their implants scanned using both the intraoral photogrammetry system IPF Elite, Shining 3D and the mobile-phone-based photogrammetry system T-Marker, following each manufacturers instructions. Both methods capture the three-dimensional positions of implants through specialized scan bodies or coded markers, generating digital datasets. These scans are compared to a reference dataset to measure linear and angular discrepancies. Chairside time for each scanning method will also be recorded to assess clinical efficiency. During the study visit, participants will undergo both scanning procedures, and the resulting digital data will be analyzed immediately for accuracy. Researchers will measure differences in implant positions and the time taken for each scan. The primary focus is on linear discrepancies between the scans and the reference data. This observational study involves adults aged 18 to 50 years with complete-arch implant-supported prostheses and aims to provide information that may help clinicians choose the best digital impression technique.

Researchers are evaluating the clinical performance of maxillary All-on-X full-arch implant-supported rehabilitation using a fully digital stackable guided surgery and immediate loading protocol. This retrospective study focuses on patients with terminal maxillary dentition treated with this approach, aiming to assess implant survival and peri-implant outcomes over a two-year follow-up. The study also investigates how surgical and prosthetic factors, including basal seating guide design, influence these results. Patients received a maxillary All-on-6 implant-supported complete fixed dental prosthesis planned through three-dimensional imaging and dedicated software. Stackable surgical guides were used to enable guided bone reduction when needed, followed by fully guided implant placement under local anesthesia. Implants with sufficient primary stability were immediately loaded with a screw-retained provisional fixed prosthesis on multi-unit abutments. The treatment followed a standardized surgical protocol with occlusal contacts minimized during healing. Participants are followed for at least two years with scheduled clinical and radiographic assessments at prosthesis delivery, one year, and two years. Outcome measures include implant survival at six months post-placement, peri-implant clinical parameters such as plaque index, bleeding on probing, probing depth, and marginal bone level changes assessed by standardized radiographs. The study collects complete clinical and radiographic records to evaluate success according to established criteria.

This research aims to compare two types of ureteral access sheaths used during flexible ureteroscopy to treat kidney stones, known as nephrolithiasis. The study focuses on a novel bendable suction ureteral access sheath with a flexible tip that can reach the renal calyces, compared to a conventional ureteral access sheath. The goal is to evaluate their effectiveness and safety in removing stones, especially for patients with stones smaller than 20 mm, where flexible ureteroscopy is considered a first-line surgical option. Participants will be randomly assigned to one of two groups one group will receive flexible ureteroscopy using the bendable suction ureteral access sheath, while the other group will receive the same procedure with the conventional ureteral access sheath. Both groups undergo minimally invasive surgery with flexible ureteroscopes, and the new device aims to improve surgical vision, reduce pressure inside the kidney, and lower infection risks during treatment. During the study, participants will be monitored for stone-free status immediately after surgery and again at three months postoperatively. Researchers will also track hospital stay duration, need for additional interventions, complications, and costs over three months. The total participation period includes surgery and follow-up assessments up to three months to measure the outcomes and safety of the two devices in treating renal stones.

Researchers are evaluating the early use of Dapagliflozin DAPA, a sodium-glucose cotransporter-2 SGLT2 inhibitor, in patients who have acute myocardial infarction AMI. The study aims to understand how early administration of DAPA before primary percutaneous coronary intervention pPCI affects infarct size, myocardial damage related to reperfusion injury, heart failure protection, and kidney protection from acute kidney injury. This investigation addresses the current gap in data on DAPAs effects in AMI patients, especially regarding heart failure prevention after AMI. Participants are randomly assigned to receive either Dapagliflozin 10 mg once daily or a matching placebo for three months. The treatment starts as early as possible before pPCI and continues for three months afterward. The study uses a double-blind design to compare the effects of DAPA versus placebo on heart and kidney outcomes in this patient group. Throughout the study, patients will undergo assessments including measurements of infarct size and NT-proBNP levels at three months, which relate to heart function and damage. Kidney function will also be monitored by changes in estimated glomerular filtration rate eGFR over the same period. These evaluations will help researchers understand the cardioprotective and renoprotective effects of early DAPA treatment in AMI. The total duration of participation involves treatment and follow-up assessments extending to three months.

Researchers are evaluating the clinical performance of implant-supported restorations made from 3D-printed permanent resin CROWNTEC compared with conventionally milled monolithic zirconia. The study focuses on single crowns and short-span fixed partial dentures in the front lower jaw, where function and appearance are important. This randomized controlled clinical trial aims to provide evidence on whether 3D-printed resin materials are a viable alternative to zirconia in implant prosthodontics. Participants are randomly assigned to two groups one receiving restorations made with 3D-printed resin using a fully digital workflow including intraoral scanning, CAD design, 3D printing, post-processing, finishing, and polishing the other group receives zirconia restorations made by CAD-CAM milling followed by sintering, finishing, and polishing. Both types of restorations are delivered as screw-retained or cement-retained prostheses. The study includes follow-up visits at baseline, 3, 6, and 12 months, with extended follow-up planned up to 24 months. During the study, participants will have assessments of restoration survival, technical complications like fracture or screw loosening, biological parameters including plaque index and probing depth, and radiographic evaluations of bone level changes. Patient satisfaction with esthetics, comfort, and chewing function is measured using questionnaires. The main outcome is the survival rate of restorations after 12 months. The study period extends up to two years, with ongoing monitoring to understand the performance and limitations of both materials.

Researchers are studying the possible effectiveness and safety of combining Diosmin and Hesperidin in treating patients with Helicobacter pylori infection. The study focuses on evaluating how this combination affects the eradication of the infection as well as its impact on inflammatory markers such as TNF-A and MDA. This is a randomized, double-blind trial involving adult patients aged 18 to 75 years who have confirmed H. pylori infection. Participants are randomly assigned to one of two groups. One group receives the standard triple therapy consisting of Omeprazole, Clarithromycin, and Amoxicillin along with placebo tablets twice daily for 14 days. The other group receives the same standard triple therapy plus DiosminHesperidin Daflon tablets twice daily for 14 days. Both treatments are administered orally. During the trial, patients are assessed at the start and six weeks after beginning therapy to measure the eradication rate of H. pylori infection using stool antigen tests. Researchers also measure levels of inflammatory biomarkers to observe any changes. Safety and response to treatment are monitored throughout the study, which lasts at least six weeks from therapy initiation.

Researchers are comparing two prostate biopsy techniques to detect prostate cancer cognitive-targeted biopsy CTB and magnetic resonance imaging-ultrasound fusion-targeted biopsy FTB. The study focuses on biopsy-nafve men suspected of having prostate cancer based on abnormal digital rectal exams and specific prostate-specific antigen PSA levels. It aims to evaluate how accurately each method detects cancer, the pathological results from each biopsy, and how the surgeons performance may affect the procedure. Participants will have a multiparametric MRI of the prostate, and only those with specific suspicious lesions PI-RADS 4 or 5 will join the trial. Each participant undergoes both biopsy methods during the same session under local or regional anesthesia, using a BK3000 ultrasound system. Two surgeons will perform the procedures, and participants are randomly assigned to one of them. This design allows a direct comparison of the two biopsy techniques within the same patient. Throughout the study, researchers will monitor various factors including cancer detection rates based on tissue analysis, clinically significant cancer rates, biopsy procedure time, lesion size on MRI, and procedural details by surgeon. These outcomes will be assessed during the biopsy session. The study is conducted at Menoufia University, with results to be reported after study completion. Participation involves a single biopsy session with detailed imaging and biopsy procedures under professional care.

Sepsis is a life-threatening condition caused by an abnormal response to infection, leading to organ failure. Septic shock is a severe type of sepsis marked by persistent low blood pressure and metabolic problems despite fluid treatment. This study aims to compare methods for predicting fluid responsiveness in patients with septic shock to improve individualized fluid therapy and prevent complications like fluid overload. Accurate prediction is especially important since traditional measures can be unreliable in diverse patient situations. The study evaluates two non-invasive methods electrical cardiometry and ultrasound assessment of the inferior vena cava IVC collapsibility. Electrical cardiometry uses advanced bioimpedance technology to measure stroke volume and cardiac output without invasive procedures. The IVC collapsibility index is measured via bedside ultrasound during the respiratory cycle. Both are assessed at baseline and after fluid challenge to monitor fluid responsiveness in critically ill patients. Participants diagnosed with hypotensive sepsis will be monitored using these non-invasive techniques as part of routine clinical care without changing their treatment. Researchers will collect data on septic shock parameters over two hours to evaluate fluid responsiveness. The study includes clinical assessments, ultrasound measurements, and hemodynamic monitoring to help guide fluid management. Participation involves standard care monitoring and non-invasive measurements during the critical illness period.

This clinical trial investigates the accuracy and speed of two digital scanning methods for capturing implant positions in completely edentulous patients who have full-arch implant-supported prostheses. The study compares a non-calibrated splinting scan body system called IoConnect with a mobile phone-based photogrammetry system named T-Marker. The goal is to determine which digital approach provides more precise implant position recording and better scanning efficiency. Participants will receive digital impressions using both IoConnect and T-Marker systems. The order in which each participant undergoes these two scanning methods will be randomized, allowing direct comparison within the same individual. Each participant has four implants in the upper jaw connected to multiunit abutments. A conventional splinted impression and master cast will serve as the reference for accuracy comparison. During a single study visit, researchers will measure the accuracy of implant position recordings by comparing digital impressions to the reference model, focusing on linear and angular deviations. They will also track the time taken for each scanning method to complete. The study aims to provide evidence about the precision and efficiency of these emerging digital workflows to help guide clinical decisions in implant prosthodontics.