Merignac

Researchers are studying how active patients recover movement and strength after hip arthroscopy surgery, specifically between 3 and 6 months post-operation. The focus is on dynamic movements like jumping, squatting, and accelerating. By analyzing how these movement parameters relate to returning to sports, along with angle and alignment measurements taken before and after surgery, the study aims to identify factors that predict rehabilitation success in athletes. This could help create more personalized rehabilitation plans. The study involves measuring the symmetry of hip muscle forces between the operated and non-operated leg in three planes, expressed as torque per body weight (Nm/Kg). These biomechanical forces will be compared between the two legs to understand recovery patterns. This diagnostic testing happens during the 3 and 6 months following surgery. Participants will be assessed through movement tests and muscle force measurements focusing on hip function and symmetry. The main outcome measured is the balance of hip muscle strength between both legs at 3 and 6 months after surgery. The study includes athletes aged 18 to 50 who had hip arthroscopy for a labrum lesion and wish to return to sport. Safety and ability to complete assessments are also monitored throughout participation.

Researchers are evaluating the dynamic biomechanical aspects of walking in active adults who have undergone total hip replacement (THR). The study focuses on movements that are important for returning to sports and physical activities after surgery. It aims to better understand how these patients move using advanced measurement tools. Participants will undergo a detailed biomechanical analysis using sensors placed on various points of both lower limbs, including the hip, knee, and ankle. These sensors, along with 3D optoelectronic cameras and force and pressure platforms, collect data on movement in multiple planes and compare both sides of the body. This assessment is performed as a procedure during the study. During the study, researchers will measure angular movements and vertical forces using biomechanical sensors six months after surgery. Participants will be monitored to track their recovery and physical performance. The study includes active patients aged 18 to 65 who are scheduled for total hip replacement and have varying levels of physical activity before surgery. The total time commitment includes assessments and follow-up at six months post-surgery.

Researchers are evaluating two treatments for persistent lumbar radicular pain (LRP) caused by a herniated disc. This condition is often treated with CT-guided epidural steroid injections (ESI), which are effective but carry rare serious risks. An alternative treatment using platelet-rich plasma (PRP), which promotes healing and reduces inflammation by delivering growth factors and cytokines, has shown promise as a potentially safer option. The study aims to compare these two treatments over a long-term period of two years. Participants will receive either an interlaminar CT-guided epidural steroid injection or an interlaminar CT-guided epidural platelet-rich plasma injection. The PRP is prepared from the participant's blood through sampling and centrifugation before injection. Both procedures are done using CT guidance to precisely deliver the treatment to the affected area in the spine. During the study, participants' functional ability will be measured at multiple times: 30 minutes before the procedure, then at 6 weeks, 6 months, 1 year, and 2 years after the procedure. These assessments will help researchers understand how well each treatment improves function over time. The study monitors safety and long-term effects through these follow-ups to provide a thorough comparison of the two approaches.

Researchers are evaluating the effectiveness of tele-rehabilitation compared to no physical therapy following total hip arthroplasty (THA). This study focuses on improving patient-reported outcomes and functional recovery after hip replacement surgery, which is commonly performed to relieve pain and restore function in various hip conditions. Traditional physical therapy is usually part of post-operative care but can face challenges due to logistical issues. Tele-rehabilitation offers a promising alternative by potentially improving access to therapy through digital means. The study has two groups: one receiving standard rehabilitation with a private physiotherapist, typically involving 15 sessions but possibly up to 25 depending on patient needs, and another receiving tele-rehabilitation. The tele-rehabilitation approach is a home-based digital program including exercises and education, with patients monitored remotely via a secure messaging system. This system uses a mobile app for patients and a web portal for physiotherapists to track daily data such as physical activity, pain, medication use, exercise adherence, and patient feedback, allowing tailored treatment adjustments. Participants are involved for a total follow-up period of 6 months. Researchers will assess functional recovery primarily through the Time Up and Go test at 6 weeks and 6 months after surgery. Secondary assessments include patient-reported outcomes, satisfaction, healthcare use, and return to physical activity. The study includes regular monitoring through the digital platform or physiotherapist visits to track progress and safety.

Ankle sprains are common injuries affecting between 2.1 and 3.2 people per 1000 each year, with nearly 40% of patients developing chronic instability within a year. Returning to sport too early increases the risk of this instability. Although experts agree on important factors to evaluate before resuming sports, no standardized tests currently exist to guide a safe return and reduce relapse risk. Surgical treatment can lower recurrence risk, but failure occurs in 13-37% of patients due to relapse or unsatisfactory return to sport. This study evaluates whether performing a combined test called ANKLE-GO three months after lateral ankle ligament repair surgery can predict successful return to sport and reduce failure risk. Patients are divided into two groups: one receives personalized physiotherapy based on the ANKLE-GO test results, while the other undergoes usual physiotherapy. The study focuses on patients who have chronic ankle instability and participate in sports at least twice weekly. Participants will be followed for one year after surgery to assess their ability to return to sport at the same level, using the Tegner questionnaire before surgery and at one year. Researchers will monitor recurrence risk and rehabilitation progress. The study includes various assessments and aims to provide objective criteria to support safe return-to-sport decisions after surgery.

Researchers are evaluating the EkiYou V2 Digital Therapy in adults with type 1, type 2, or pancreatic diabetes who use multiple daily insulin injections. This multicenter randomized controlled trial involves 154 adults treated with basal-bolus insulin regimens and continuous glucose monitors (CGM). The study aims to compare EkiYou V2 with standard care for insulin dose management and to assess participant satisfaction, user experience, and quality of life. Participants will be randomly assigned to two groups. One group will use the EkiYou V2 mobile application from the start for six months. The other group will continue standard care for the first three months and then receive EkiYou V2 for the last three months. The device helps estimate daily bolus and basal insulin doses and adjusts insulin parameters weekly, including basal insulin dose, insulin-to-carb ratios, and correction factors. It also provides carbohydrate counting with a large food database, bolus calculation based on meals, physical activity, and blood glucose, bolus correction advice, insulin reminders, and automatic titration. Participants will attend three visits over six months, including at study start. Researchers will monitor glucose data via CGM devices and collect quality of life and satisfaction data through electronic questionnaires. The main outcome measured is the change in the percentage of time blood glucose levels are in the target range (70-180 mg/dL) after three months compared to baseline. Safety and adherence will be tracked throughout the study period.

Researchers are collecting and evaluating long-term data on clinical and radiographic outcomes to better understand the safety and performance of shoulder arthroplasty over time. This study includes people with various shoulder conditions such as osteoarthritis, osteonecrosis, rotator cuff tears, rheumatoid arthritis, fractures, and infections. The trial will follow participants for at least 10 years, with no early limit on follow-up duration. The study includes patients who are either scheduled for shoulder arthroplasty or have already undergone the procedure. Participants must be skeletally mature and expected to survive at least two years beyond surgery. The study is open-label and multi-center, involving both retrospective and prospective data collection. There are no specific interventions or treatments being compared, as the focus is on observing outcomes after shoulder arthroplasty. Participants will undergo assessments including clinical and radiographic evaluations at an average of once per year throughout the study. Outcome measures include the Constant score, ASES (American Shoulder and Elbow Surgeons) score, Oxford Score (optional in the UK), TESS, and MSTS scores related to pre-operative conditions. Researchers will monitor participants for safety and implant performance during the long-term follow-up, which can last a minimum of 10 years.

Researchers are comparing two techniques for total knee prosthesis (TKA) placement in adults with knee osteoarthritis: the traditional Mechanical Alignment (MA) and the newer Kinematic Alignment (KA). MA uses fixed bone cuts based on mechanical axes and does not restore the knee's natural anatomy, which can lead to altered knee biomechanics and dissatisfaction in some patients. KA aims to personalize the prosthesis placement by restoring each patient's unique pre-arthritic knee anatomy, even if severe limb deformities remain. The study focuses on understanding how these techniques affect knee biomechanics after surgery. Participants receive either a kinematically aligned knee prosthesis or a mechanically aligned prosthesis. The KA group includes patients who have a follow-up consultation at least one year after surgery. The MA group consists of patients matched by sex, age, and BMI who also have a consultation one year after their TKA. Both groups undergo evaluation to compare clinical, stereoradiographic, and biomechanical outcomes. During the study, participants attend a follow-up consultation one year after their knee replacement surgery. Researchers assess various biomechanical parameters of the knee, including spatiotemporal factors, kinematic movements in three planes, joint moments, forces, lever arms, and symmetry between the operated and healthy limbs. These measurements help evaluate the impact of alignment techniques on knee function and prosthesis performance over time.

Researchers are comparing two types of total knee prostheses designed for use with the kinematic alignment technique in patients undergoing initial total knee replacement for knee osteoarthritis. This study aims to evaluate how well patients perceive their prosthetic joint, alongside clinical and imaging results, knee biomechanics during walking, and knee extension muscle strength with each prosthesis. The study addresses dissatisfaction seen in some patients with traditional mechanical alignment prostheses by focusing on restoring the knee's unique anatomy and laxity. Participants will receive total knee arthroplasty using either the SPHERIKA prosthesis by Medacta or the ORIGIN prosthesis by Symbios, both developed to work with the kinematic alignment surgical technique. The interventions involve implanting the prostheses in the knee to better replicate natural knee mechanics. This randomized trial will assess and compare outcomes between these two prostheses during the recovery process. During the study, patients' joint perception will be measured using the "forgotten joint score" at multiple time points: two months before surgery, 45 days after surgery, one year after surgery, and two years after surgery. Additional assessments include clinical exams, imaging studies, biomechanical analysis of gait, and muscle strength tests. The study requires informed consent and follow-up over an extended period to monitor outcomes and safety.

Very little information is available about hypoparathyroidism, a condition that can lead to complications such as low calcium symptoms, calcifications in various tissues, kidney stones, and kidney problems. No specific data exists for France, so researchers are gathering detailed information about the condition, its treatments, and related complications in French patients. This research aims to better understand how hypoparathyroidism affects people in France over about two years. No treatments or interventions will be given as part of this study. Instead, the study will collect and analyze existing data on patients diagnosed with chronic hypoparathyroidism who live in France. This approach allows researchers to observe real-world experiences without changing patient care. Participants will provide information that helps assess the overall patterns, treatments, and complications related to hypoparathyroidism. This includes tracking how common the condition is and monitoring any complications during the study. The study will continue until its completion, which is expected to be around two years, focusing on gathering comprehensive epidemiological data.