Kota Jakarta Pusat

Researchers are evaluating the effectiveness of the tetravalent dengue vaccine (TDV) in reducing hospital stays due to dengue virus infections among children and adolescents in Southeast Asian countries with high dengue transmission, specifically Thailand, Indonesia, and Malaysia. This study focuses on participants aged 6 to 12 years who are part of a community-based cohort and may or may not receive TDV as part of a pilot public vaccination program. The research aims to provide further information on TDV's effectiveness, especially against the less common dengue virus types DENV-3 and DENV-4. This is a non-interventional study where participants are observed over a period of three years. Some cohort members may receive the TDV vaccine as part of a public vaccination program, while others may not be vaccinated. Researchers will compare hospitalization rates due to dengue between vaccinated and unvaccinated participants, without administering any study-specific treatments or interventions. Participants will be followed individually for three years, with their health monitored to identify any hospital stays caused by dengue infections. Blood samples may be collected at baseline and during illness episodes to confirm dengue infection using laboratory tests like RT-PCR. The primary outcome measured is hospitalization due to virologically confirmed dengue of any serotype. The study also includes matched case-control analyses within the cohort to better understand vaccine effectiveness and safety.

Researchers are examining the characteristics of skin aging by studying clinical examination results, the Dermoscopic Photoaging Scale (DPAS), and leucocyte telomere length. This study focuses on understanding how these factors relate to skin aging in adults aged 29-31 years and 59-61 years. Skin aging includes natural changes and damage caused by environmental factors like UV exposure, smoking, and pollution, with typical signs such as wrinkles and pigmentation changes. The Glogau scale and DPAS score are used to assess the severity of photoaging in different facial areas. Participants will undergo a clinical skin examination by a dermatovenereologist, including photographs taken from five angles. Dermoscopy will be performed on the forehead, right cheek, left cheek, and chin to calculate the DPAS score based on 11 parameters. Blood samples (about 10 mL) will be collected to measure leucocyte telomere length using PCR methods. These assessments will help profile skin aging and telomere length in the study groups. During the study, researchers will evaluate the profiles of leucocyte telomere length, the Glogau scale clinical examination, and the DPAS score over one year. The study includes detailed skin assessments, imaging, and genetic testing through blood draws. Participants' skin aging signs will be closely monitored to understand the link between telomere length and skin aging, with safety and condition monitoring throughout the study period.

Researchers are conducting a phase I clinical trial to study the use of autologous natural killer (NK) cell therapy in patients with liver cancer, specifically hepatocellular carcinoma (HCC) at Barcelona Clinic Liver Cancer (BCLC) stages B and C, and with Child-Pugh A classification. The study aims to find the optimal treatment dosage, observe any side effects, and measure the average progression-free survival time. Participants are patients who received care at Cipto Mangunkusumo Hospital between May and December 2022 and meet specific eligibility criteria. The treatment involves intravenous administration of autologous NK cells isolated using the Clinimacs Plus device, which is an automated system designed to separate clinically labeled cells with MicroBeads technology. Each participant will receive this therapy following established guidelines for NK cell isolation. The study sample includes 2-3 patients to evaluate dosing and side effect occurrence. Participants will be monitored from the start of NK cell infusion (Day 0) for up to six months to assess treatment dosage and effects. Researchers will evaluate blood parameters, liver and kidney function, and overall health status. The trial focuses on safety, dosage optimization, and progression-free survival in this patient group.

Researchers are evaluating the functional outcomes of patients who have experienced an anterior cruciate ligament (ACL) rupture and undergo ACL reconstruction surgery using hamstring grafts. The study compares two surgical techniques: the all-inside technique and the complete tibial tunnel technique. The hamstring graft, taken from the patient's posterior thigh, replaces the torn ligament during reconstruction to restore knee stability. Participants will be randomly assigned to receive ACL reconstruction with either the all-inside technique, which uses retrograde drilling to create bone sockets and adjustable-loop suspensory fixation, or the complete tibial tunnel technique, which involves creating full-length bone tunnels and securing the graft with a bio-interference screw and fixed-loop suspensory device. Both surgical procedures use the patient's own hamstring graft as the tissue substitute. Throughout the study, patients will be evaluated before surgery and at 3, 6, 9, and 12 months after surgery. Assessments include measuring tibial translation, pain severity using visual analogue scales, International Knee Documentation Committee (IKDC) scores, Tegner-Lysholm knee scores, and intra-operative hamstring graft diameter. Follow-up visits include physical exams and clinical evaluations at the outpatient orthopedic clinic to monitor recovery and surgical outcomes.

Researchers are evaluating the effects of spinal anesthesia adjuvant versus quadratus lumborum block on opioid use and pain during and after surgery in patients undergoing laparoscopic kidney transplant donation. The study focuses on managing pain and reducing opioid requirements in this specific surgical population aged 18 to 65 years with certain health conditions. Participants are assigned to receive either spinal anesthesia adjuvant, which includes a combination of bupivacaine, morphine, sulfas atropine, and saline before anesthesia induction, or quadratus lumborum block, which involves injections of bupivacaine after anesthesia induction and surgery. All subjects undergo general anesthesia with medications including lidocaine, fentanyl, propofol, rocuronium, and dexamethasone, along with airway management via endotracheal intubation. During the study, researchers monitor postoperative pain levels and opioid use at 2, 6, 12, and 24 hours after surgery. The trial focuses on detailed pain assessment and opioid consumption to compare the two anesthesia techniques. Participants are observed closely throughout the perioperative period to assess safety and effectiveness of the pain management approaches.

Researchers are evaluating treatments for melasma, a skin pigmentation disorder causing brownish patches primarily on sun-exposed facial areas, often affecting women with Fitzpatrick skin types IV to V. This clinical trial compares three therapies: intradermal concentrated secretome injection, triple combination cream, and intradermal tranexamic acid injection. The study also aims to assess the quality of life of melasma patients following triple combination cream treatment and to measure superoxide dismutase (SOD) levels. Participants are divided into three groups of 30. Group A receives secretome injections at weeks 0, 4, and 8 alongside 0.5% tretinoin cream and sunscreen. Group B uses triple combination cream nightly with facial wash and sunscreen, evaluated every 4 weeks. Group C receives tranexamic acid injections every 2 weeks plus 0.5% tretinoin cream and sunscreen. All groups undergo initial and periodic assessments including physical exams, clinical photos, modified Melasma Severity Index (mMASI) scoring, dermoscopy, Wood's lamp examination, and mexameter measurements over 12 weeks. Participants attend evaluations at scheduled intervals (weeks 0, 2, 4, 6, 8, and 12 depending on group) where melasma severity (mMASI), patient tolerability, melanin and erythema indices, and quality of life (MelasQoL-INA) are measured. Data are statistically analyzed to compare treatment effects. Safety and adherence are monitored through clinical assessments, and the study duration for each participant is 12 weeks.

Researchers are studying overweight and obese adolescents aged 12 to 17 years to understand how probiotic supplements combined with healthy eating, physical activity counseling, and psychosocial stimulation affect their nutritional status and immune response to COVID-19 vaccination. This study is a randomized controlled trial conducted in junior and senior high schools across Jakarta, Surabaya, and Yogyakarta, Indonesia. Adolescents in this study have completed at least two doses of the CoronaVac COVID-19 vaccine and are at least six months post-vaccination. The study aims to explore how probiotics influence gut microbiota, nutrition, and antibody response to SARS-CoV-2 during adolescence, a critical period for microbial changes and vulnerability to infections. Participants will receive either a combination of three probiotic strains (Lactobacillus rhamnosus, Bifidobacterium animalis subsp. lactis, and Lactobacillus acidophilus) or a placebo (maltodextrin) as dietary supplements. Alongside this, all participants will receive counseling on healthy eating, physical activity, and psychosocial stimulation. The intervention will last for 20 weeks, aiming to promote beneficial gut bacteria, improve nutrition, and potentially enhance immune response. Throughout the 20-week study, researchers will monitor participants' body mass index for age (BMI-for-age z-scores) at weeks 5, 10, 15, and 20, as well as measure immunoglobulin G (IgG) antibody levels specific to SARS-CoV-2 at weeks 10 and 20. The study includes regular assessments of nutritional status and immune response to COVID-19 vaccination. Safety and health will be closely monitored, with COVID-19 prevention measures in place during face-to-face activities. The total duration of involvement is 20 weeks, with ongoing observation of health and antibody levels.

This research aims to examine the links between dietary habits, hair zinc levels, body composition, inflammation, and blood pressure in women of reproductive age from various ethnic groups living in Jakarta, Indonesia. The study focuses on women from Minangkabau, Sundanese, Javanese, Betawi, and Chinese backgrounds to understand how diet and zinc status might influence these health factors. Participants will not receive any treatment, as this is an observational study. They will complete dietary assessments including a semi-quantitative food frequency questionnaire and a 3-day food diary. Body composition will be measured using the BOD POD device, which assesses weight, height, fat mass, and fat-free mass. Biological samples of blood and hair will be collected to analyze levels of tumor necrosis factor alpha (TNF-α) and hair zinc concentration. Each participant will be assessed once during the study. Researchers will collect data on dietary zinc intake, diet quality, planetary health diet index, ultra-processed food intake, body composition, hair zinc concentration, and blood pressure. These measurements will help identify associations between diet, inflammation, zinc status, body composition, and blood pressure in this urban female population.

Researchers are studying whether Cognitive Behavioral Therapy (CBT) can improve psychological, neurological, and hormonal factors in women undergoing In Vitro Fertilization (IVF). The study aims to find out if CBT helps reduce anxiety and depression, improve coping mechanisms, and positively affect hormone levels such as cortisol, norepinephrine, and free triiodothyronine in these women. The trial compares the effects of CBT against no intervention. Participants will attend eight weekly appointments where they either receive CBT or no intervention. Their anxiety, depression, and coping mechanisms will be assessed before the first appointment and again at the third, sixth, and eighth sessions. Hormone levels including cortisol, norepinephrine, and free triiodothyronine will also be tested at these same time points. Throughout the study, researchers will measure changes in psychological scores and hormone levels from baseline (one month before starting IVF or one week before pre-IVF counseling) to various points during the IVF program. These assessments help track improvements over time. Participants are involved for the duration of the eight-week therapy or observation period to monitor these outcomes and evaluate the effectiveness of CBT.

This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery. The goal is to determine which method leads to a more optimal and precise amount of fluid administration. The objective is to compare the total fluid volumes administered when guided by Cardiac Index versus Central Venous Pressure, as well as mortality, length of stay, relaparotomy and reintubation in order to identify the more precise fluid management strategy for postoperative ICU patients.