Lahore

This research aims to compare the effectiveness of topical lignocaine ointment versus 0.2% glyceryl trinitrate GTN ointment for reducing postoperative pain and promoting wound healing in patients undergoing hemorrhoidectomy. Hemorrhoids are swollen veins in the anal area, and pain after surgery can delay recovery and affect comfort. The study focuses on determining which ointment provides better pain relief and wound healing outcomes following hemorrhoid removal surgery. Patients undergoing hemorrhoidectomy will be randomly assigned to one of two groups. One group will receive lignocaine ointment applied locally to the anal wound three times daily after surgery, while the other group will receive 0.2% GTN ointment on the same schedule. Both groups will receive standard postoperative care including sitz baths, stool softeners, and paracetamol for pain relief. The study will follow participants for 3 to 6 months overall, with treatment and monitoring focused on the first month after surgery. Participants will have their pain levels assessed using a visual analog scale VAS at various times after surgery, including 6, 12, 24, 48, and 72 hours, as well as at 7, 14, 21, and 28 days. Wound healing time will be tracked up to one month, and patient satisfaction will be measured at 6 weeks using a 5-point scale. Additional monitoring includes recording the time to first analgesic request, analgesia amounts, and any side effects such as wound secretion, itching, bleeding, or headaches. Data will be analyzed to compare outcomes between the two ointments.

Road traffic accidents cause significant health problems worldwide, leading to many injuries and deaths. This research evaluates the feasibility and acceptability of Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol for Ongoing Traumatic Stress EMDR-IGTP-OTS to reduce post-traumatic stress symptoms, depression, and anxiety, and to improve quality of life in people who survived traffic accidents. The study uses a randomized control design involving adults aged 18 to 45 years, assessing outcomes before treatment, after treatment, and at one-month follow-up. Participants will be randomly assigned to receive either the EMDR-IGTP-OTS group therapy, which combines EMDR eight-phase protocols with the Butterfly hug technique, or to a control group with no intervention. The study evaluates how well this group therapy works and how acceptable it is for people recovering from ongoing traumatic stress due to road accidents. During the study, participants are assessed at three points using the Urdu Impact of Event Scale-Revised UIES-R, Depression Anxiety Stress Scales DASS-21, and the World Health Organization Quality of Life Questionnaire WHOQOL-BREF. The research team will monitor symptom changes and quality of life improvements over four weeks. The total study duration spans from enrollment through a one-month follow-up, aiming to support trauma-focused care in diverse and resource-limited settings.

Researchers are conducting an 18-month Phase 3 study to evaluate the safety and effectiveness of oral nizubaglustat AZ-3102 in children and adolescents with late-infantile and juvenile forms of Niemann-Pick type C disease. This randomized, double-blind, placebo-controlled trial aims to show whether nizubaglustat improves ataxic symptoms compared with placebo. The study also assesses other neurological and behavioral effects, pharmacokinetics, pharmacodynamics, and safety of the treatment. Participants receive either daily oral dispersible tablets of nizubaglustat or matching placebo. The study follows a parallel design with random assignment to treatment groups. The treatment period lasts for 18 months, during which participants take the assigned medication once daily. The study monitors treatment effects and safety throughout this period. During the trial, participants undergo assessments including the Scale for the Assessment and Rating of Ataxia SARA, Vineland Adaptive Behavior Scale, Penetration-Aspiration Scale, 9-Hole Peg Test, and other neurological and functional tests at baseline and at months 6, 12, and 18. Blood samples are collected to study drug levels and biomarkers. Researchers also track seizure frequency and adverse events. The primary outcome measures focus on changes in total and functional SARA scores from baseline to month 18, with safety and tolerability evaluated throughout participation.

Researchers are conducting an 18-month Phase 3 study to evaluate the safety and efficacy of oral nizubaglustat AZ-3102 in children aged 4 years and older diagnosed with late-infantile or juvenile forms of Niemann-Pick type C disease, GM1 gangliosidosis, or GM2 gangliosidosis. This randomized, double-blind, placebo-controlled, multicenter trial uses a Master Protocol Research Program to study these related conditions in separate subprotocols based on disease type. Participants are randomly assigned in a 21 ratio to receive either oral nizubaglustat tablets or a matching placebo. The treatment and procedures are specific to each disease subprotocol, detailing different eligibility requirements, safety assessments, and efficacy endpoints. The study includes subprotocols for Niemann-Pick type C disease and for GM1 or GM2 gangliosidosis, each with tailored treatment plans and monitoring. Throughout the study, participants will undergo evaluations as described in their respective subprotocols, which may include clinical assessments, safety monitoring, and outcome measurements over the 18-month period. Researchers will track participant allocation to each subprotocol as the primary outcome. The trial is designed to monitor safety and treatment effects closely until the study completes in 2028, with detailed procedures provided within each disease-specific subprotocol.

Post-lobectomy patients often face respiratory challenges such as mucus buildup, difficulty breathing, and reduced lung function, which can delay recovery. Researchers are evaluating the effects of two devices, Acapella and Flutter, which use oscillatory positive expiratory pressure OPEP to help clear airways and improve lung function. This study compares these devices to understand their impact on secretion clearance, breathing difficulties, blood gases, and lung performance after lobectomy surgery. Participants will be divided into two groups. One group will use the Acapella device, which combines positive expiratory pressure and airway vibrations, while the other will use the Flutter device that generates oscillatory pressure during exhalation. Both groups will perform airway clearance therapy twice daily for seven days following a standardized protocol, alongside standard post-lobectomy care. Throughout the study, participants will be monitored on postoperative days 1, 3, and 5 for changes in breathing difficulty scores, lung function tests including forced expiratory volume and vital capacity, and arterial blood gas measurements. Researchers will also measure sputum volume and key blood parameters to assess respiratory recovery. The study aims to provide detailed information on how these devices support lung function during the critical postoperative period.

This research aims to compare two manual therapy techniques, Active Release Technique and Strain-Counterstrain, in adults aged 18 to 45 years who experience non-specific neck pain. The study focuses on how these treatments affect pain levels, neck range of motion, the cranio-vertebral angle, and disability. Neck pain is a common problem worldwide and in Pakistan, often caused by muscle strain or poor posture, leading to discomfort and reduced quality of life. This trial seeks to provide insights into which technique may better improve symptoms and function in affected individuals. Participants will be randomly assigned to one of two groups. Group A will receive the Active Release Technique applied to the trapezius, levator scapulae, sternocleidomastoid, and suboccipital muscles for 15 minutes. Group B will receive the Strain-Counterstrain technique on the same muscles and for the same duration. Both groups will also receive hot packs, stretching of superficial neck muscles, and neck isometric exercises. Treatments will be given over four weeks, with assessments at the start and end of this period. During the study, participants will be evaluated for pain using the Numeric Pain Rating Scale, neck disability with the Neck Disability Index, neck posture by measuring the cranio-vertebral angle, and neck mobility with a goniometer. These measurements will be recorded at the beginning and after four weeks of treatment. The study will be conducted at Safi Teaching Hospital in Faisalabad, Pakistan, with ethical approval and informed consent. The findings aim to help improve clinical care for people with non-specific neck pain by identifying more effective manual therapy options.

Down syndrome is a genetic condition caused by an extra copy of chromosome 21, affecting about 1 in 800 newborns worldwide. This research aims to compare the effects of aerobic exercise alone versus aerobic exercise combined with a low calorie diet on reducing body fat and improving body mass index BMI in overweight and obese children with Down syndrome. The study focuses on children aged 8 to 16 years who have a BMI at or above the 85th percentile, representing overweight or obesity status. The trial includes two groups one group will participate in aerobic exercise combined with a low calorie diet following an intermittent fasting plan, while the other group will do aerobic exercise without any specific diet changes. The aerobic exercise involves warm-up and cool-down sessions, with the diet consisting of fasting periods increasing over 12 weeks. The study is randomized and conducted over a total duration of 10 months, with a sample size of 22 participants. Participants will be assessed using a digital weight scale and BMI calculator at the start and at 12 weeks. Additional evaluations include waist circumference, aerobic fitness via a 6-minute walk test, skin-fold measurements, perceived exertion scales, and food frequency questionnaires. The study monitors changes in adiposity and BMI to provide insights into the best approach for weight management in children with Down syndrome. Data will be analyzed using SPSS software, and all participants will be supervised closely throughout the trial.

Researchers are evaluating the effects of two popular warm-up protocols, FIFA 11 and RAMP, on agility and sprint performance in young male soccer players aged 8 to 15. This randomized clinical trial aims to fill a gap in sports science by directly comparing these warm-ups to guide coaches in optimizing athlete development and reducing injury risk during crucial developmental years. Participants will be randomly assigned to perform either the FIFA 11 or the RAMP warm-up protocol before each training session for six weeks. The FIFA 11 is a 20-minute program with 15 exercises focusing on neuromuscular control and injury prevention, divided into slow-speed running, strength and balance exercises, and high-intensity running drills. The RAMP protocol is also 20 minutes long, featuring four phases Raise, Activate, Mobilize, and Potentiate, designed to progressively prepare athletes for high-intensity activity. Each group will complete a total of 18 sessions, training three times per week. Participants will undergo assessments at baseline, the first week, and after six weeks, including the Illinois Agility Test to measure agility and a 30-meter sprint test to evaluate sprint speed. Data will be analyzed to compare improvements between the two groups. This study includes monitoring of performance outcomes and aims to provide evidence-based recommendations for warm-up routines. The total study duration spans the six-week intervention period, with evaluations conducted at specified intervals.

Researchers are collecting prospective data from about 200 patients who receive alloplastic total temporomandibular joint TMJ replacements. This registry aims to understand the clinical reasons for TMJ replacement, treatment patterns across regions, patient outcomes including pain, jaw movement, and quality of life, as well as reasons why some patients refuse this surgery. The study is observational and does not assign specific treatments but records routine care provided by individual clinicians. Patients undergoing TMJ replacement will be followed for up to 5 years after their surgery, with assessments at multiple time points including 10 days, 3 months, 6 months, 12 months, 24 months, and 60 months. Data collected include treatment details, clinical evaluations such as mandibular movements and occlusal status, patient-reported outcomes like pain and diet limitations, as well as radiological parameters and any complications that occur. Cases of patients who refuse the TMJ replacement will also be registered. Participants will be monitored through pre-operative and post-operative assessments covering functional outcomes, quality of life questionnaires, and imaging studies. Researchers will track adverse events, survival, and other clinical factors over the five-year period. The registry collects detailed data on demographics, comorbidities, and treatment outcomes to explore predictors of favorable results and improve understanding of TMJ replacement effects.

Researchers are investigating whether Aloe Vera gel dressing reduces pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adults aged 18 to 60 years. This trial aims to see if Aloe Vera leads to improved pain control seven days after surgery and whether it reduces the need for additional pain medication. The study is conducted at the Department of Plastic Surgery over six months and compares two dressing types applied after skin graft surgery. Participants will be randomly assigned to one of two groups one group receives Aloe Vera gel dressing applied directly to the donor site, followed by dry gauze and crepe bandage as secondary dressings. The other group receives conventional paraffin-based tulle dressing with chlorhexidine applied to the donor site, also followed by dry gauze and crepe bandage. All skin grafts are harvested under general anesthesia using a uniform thickness. The dressings are applied immediately after graft harvesting. During the study, pain will be measured using a visual analogue scale VAS on the seventh day after surgery. If participants report a pain score of 4 or higher, they will receive pain medication, and the amount used will be recorded. Researchers will compare the pain scores and analgesic use between the two groups. The total participation time includes surgery and follow-up for at least seven days after surgery to assess pain at the donor site.