Tokat Merkez

Researchers are evaluating AZD0780, an oral PCSK9 inhibitor, in a phase 3, randomized, placebo-controlled study. This trial focuses on patients with established atherosclerotic cardiovascular disease ASCVD or those at high risk for a first ASCVD event. The study aims to assess how AZD0780 compares to placebo in reducing the risk of major adverse cardiovascular events, also known as MACE-PLUS, over the course of the trial. Participants are randomly assigned to receive either oral AZD0780 once daily or a matching placebo once daily. The study continues until a primary analysis censoring date, which may be up to approximately 54 months from randomization. After this, a study closure visit will be conducted as the final visit for each participant. During the study, participants will be regularly monitored for cardiovascular events including heart attacks, strokes, urgent coronary revascularizations, and other related outcomes. Researchers will track the time to first occurrence of these events as the primary outcome. Safety and other secondary outcomes like all-cause mortality will also be assessed. The total participation time can last up to about 54 months, with ongoing evaluations throughout this period.

Researchers are evaluating the impact of a training program based on the ARCS Motivation Model on nursing students communication skills, learning motivation, and self-confidence. This study focuses on first-year nursing students who are starting their clinical practice for the first time. The ARCS model emphasizes Attention, Relevance, Confidence, and Satisfaction to improve learning motivation and outcomes. The study uses a randomized controlled design to compare students receiving ARCS-based training with those receiving traditional education. The study divides participants into two groups an experimental group receiving ARCS Motivation Model education and a control group receiving traditional nursing education. The ARCS-based program uses teaching materials and group activities built around its four key components. The intervention aims to enhance communication skills, motivation, and self-efficacy among nursing students. The training occurs during the students clinical practice period. Participants will be assessed one week before and two weeks after the intervention using several tools, including the Effective Communication Skills Scale, Learning Motivation Scale, and Self-Efficacy Scale. The study requires attendance at all training sessions and collects demographic information. Researchers will monitor communication abilities, motivation levels, and self-confidence changes to determine the programs effects. The study is scheduled to start in May 2025 and continues until June 2025.

Researchers are evaluating ziltivekimab, a new medicine not yet approved anywhere, to see if it can help people who were hospitalized due to a heart attack. The study aims to find out if ziltivekimab can reduce the development of heart disease and prevent future heart attacks or strokes. This is a Phase 3 clinical trial comparing ziltivekimab to a placebo in patients with acute myocardial infarction. Participants will receive an initial loading dose of ziltivekimab or matching placebo by injection under the skin as soon as possible after an invasive heart procedure, within 36 hours for STEMI or 48 hours for NSTEMI patients. After the loading dose, they will get monthly injections of the same study medicine for up to two years, in addition to their standard care. During the study, participants will be monitored for major cardiovascular events such as heart attack, stroke, and cardiovascular death. Researchers will also track other heart-related outcomes and safety measures over a period of up to 25 months. The study involves regular visits for injections, assessments, and laboratory tests to evaluate the medicines effects and patient health throughout the trial.

Researchers are evaluating a novel rapid diagnostic device designed to detect Crimean-Congo Hemorrhagic Fever CCHF at the point of care in secondary health care clinics in Turkey. This study aims to determine the sensitivity and specificity of the test using samples of whole blood, serum, and capillary blood from adults suspected of CCHF infection. The goal is to meet or exceed the World Health Organizations minimum sensitivity of 90% and specificity of 80% for this condition. The study involves using a rapid diagnostic test RDT developed by the Liverpool School of Tropical Medicine and Global Access Diagnostics. This device detects CCHF viral antigens quicklyproviding results within 20 minutesand is simpler and more affordable than the standard RT-PCR test. Participants suspected of infection will have blood drawn and tested with the RDT at four endemic secondary health care sites in Turkey. Participants will provide blood samples which will be compared against PCR testing to evaluate the accuracy of the new device. The study will also collect questionnaires from end users to assess usability. Researchers will measure diagnostic sensitivity, specificity, predictive values, test accuracy, and the time taken to obtain results. The study includes follow-up until all diagnostic results and questionnaires are received, which may take up to a month after the last participant is recruited.

Researchers are evaluating the effects of a mindfulness-based postpartum discharge education program on mothers perception of their maternal role and their anxiety levels after childbirth. This observational study involves 84 postpartum women divided into an experimental group and a control group to compare the impact of the mindfulness education against standard hospital discharge care. Within the first 24 hours after delivery, mothers in the experimental group receive a 60-minute individual mindfulness-based education session in addition to routine discharge care. The control group receives only the standard discharge education. One week later, both groups complete a second assessment. The experimental group then receives weekly follow-up reminders and monitoring via WhatsApp for one month. At the end of the first postpartum month, final assessments are conducted. Participants will complete questionnaires including the Maternal Role Perception Scale and the Postpartum Specific Anxiety Scale at baseline, one week, and one month postpartum. Researchers will analyze changes over time and compare groups using statistical methods. The study includes systematic follow-up through weekly messages and monitoring charts to track adherence and outcomes over the month. Total participation lasts about one month from delivery.

Researchers are evaluating whether measuring peripheral venous pressure PVP can better guide the need for diuretic treatment and improve long-term outcomes such as mortality, hospital readmissions, and emergency visits in patients hospitalized with heart failure compared to standard evaluation methods. This study focuses on adults aged 18 to 99 with new or worsened chronic heart failure, regardless of heart function or cause. The trial aims to address the challenge of persistent congestion after hospital discharge, which contributes to high readmission and death rates. Participants will be randomly assigned to two groups one receiving diuretic therapy guided by PVP measurements aiming for a PVP less than 9 mmHg before discharge, and the other receiving standard diuretic therapy based on physician judgment. Peripheral IV lines will be placed to measure PVP using a defined procedure, and treatment will follow European Society of Cardiology guidelines. Patients unable to have PVP measured or requiring intensive support will be excluded. The study will last one year, with follow-up to track major adverse events including death and hospital readmissions. During the study, participants will undergo blood sampling, electrocardiogram, echocardiogram, daily monitoring of fluid intake and output, weight, and biochemistry tests. Data will be collected electronically, and PVP measurements taken at admission and before discharge will be analyzed for correlation with outcomes. Researchers will also evaluate kidney function changes and hospitalization patterns. The study involves 650 participants and includes statistical analyses to compare the two treatment approaches over one year.

This research aims to examine how Electronic Fetal Monitoring EFM training given to midwifery students through a peer education method affects their knowledge, skills, and confidence in using EFM. The study is an experimental design with randomized controlled pre-test and post-test assessments. It focuses on second-year midwifery students who have not previously received EFM training and are taking the Prenatal Period-I course for the first time. Participants first receive standard training on EFM consisting of two 50-minute lessons using an 80-slide PowerPoint presentation and a Leopold Maneuver Palpation Model. After standard training, students are randomly assigned to either a peer tutoring group or a standard education group. The peer tutoring group receives additional peer education where students teach each other in small groups using the same materials. Both groups then apply EFM techniques in clinical practice with pregnant women. During the study, students knowledge and self-efficacy related to EFM are evaluated before and after training using a personal information form, an achievement test, and a self-efficacy scale. Their skills are monitored in real time during EFM application on pregnant women using a skill form. The primary outcomes are assessed shortly after training and clinical application. The study continues to evaluate students performance throughout their clinical practice until completion.

Researchers are investigating the effectiveness of synchronous telerehabilitation for patients with elevated pulmonary artery pressure of 50 mmHg or higher, identified by echocardiography. The study aims to determine if this real-time, supervised telerehabilitation can improve exercise capacity, functional status, dyspnea, fatigue, psychological health, and quality of life compared to breathing and posture exercises. This trial addresses the limited evidence on telerehabilitation for this patient group and explores a possible accessible alternative to center-based rehabilitation. Participants will be randomly assigned to one of two groups for an 8-week program. One group will receive supervised synchronous telerehabilitation via videoconferencing, including aerobic, endurance, and strengthening exercises performed three times weekly for 30 minutes per session. The control group will perform breathing, posture, and breathing control exercises alongside routine care and receive weekly motivational support. After eight weeks, control group participants may opt to join the telerehabilitation program. Throughout the study, participants will undergo assessments before and after the intervention to measure exercise capacity, dyspnea severity, fatigue, physical activity, anxiety, depression, pulmonary function, quality of life, and independence in daily activities. During exercise sessions, vital signs and symptoms will be monitored closely. The total participation lasts 8 weeks with detailed evaluations to assess the impact of the telerehabilitation approach.

Researchers are investigating how different deproteinization agents affect the success of non-invasive fissure sealant applications on permanent teeth. This study focuses on preventing or stopping early enamel caries in high-risk tooth surfaces by comparing two agents sodium hypochlorite NaOCl and hypochlorous acid HOCl. The trial aims to provide new clinical evidence on the effectiveness of HOCl, which has shown promising antimicrobial and tissue-tolerated properties in dental care. Participants in this trial receive fissure sealant treatment combined with one of two deproteinization agents applied before acid etching 5.25% sodium hypochlorite, known for its adhesion benefits but with some disadvantages such as irritation risk and bad odor, or hypochlorous acid, a newer, less acidic agent produced by the bodys immune cells with reported biocompatibility and antimicrobial activity. The study randomly assigns children to one of these groups and monitors the clinical success of the sealants over time. Children aged 6 to 9 with newly erupted permanent lower first molars suitable for sealant application are followed up at 6, 12, 24, and 36 months after treatment. Researchers assess sealant retention and edge integrity using established criteria to measure outcomes. The study includes behavior assessments and excludes children with certain dental or systemic conditions. Participation involves regular dental check-ups to evaluate the sealants condition and any changes in the treated teeth.

Researchers are studying how different deproteinizing agents affect the success of fissure sealants applied to primary teeth. This research focuses on preventing or stopping early caries tooth decay on high-risk tooth surfaces using a non-invasive method. The study compares traditional sodium hypochlorite, known for improving adhesion but with some drawbacks, to hypochlorous acid, a newer agent believed to be gentler and effective with antimicrobial properties. The study involves two treatment groups where one group receives sodium hypochlorite and the other receives hypochlorous acid for enamel deproteinization before fissure sealant application. Both agents work by removing organic material from the tooth surface to improve sealant adhesion. The study is designed as a randomized, single-blind clinical trial in a split-mouth format, meaning each participant will receive both treatments on different teeth for comparison. Participants will be monitored at 3, 6, 12, and 24 months after sealant application. During these visits, researchers will evaluate the sealants success using the Modified Simonsen Criteria and assess the integrity of the sealant edges. The study includes children aged 4 to 6 years who meet specific dental and behavioral criteria. The total participation period spans two years to observe the long-term effects of the treatments on the sealants.