Long-Term Observational Study on Relapsing Polychondritis and Vasculitis to Understand Disease Causes and Progression

What this Trial Is About

Relapsing polychondritis RP is a rare inflammatory disease that causes recurring inflammation of the cartilage in areas like the ears, nose, airways, chest wall, and joints. It can also affect other parts such as the eyes, blood vessels, nervous system, skin, and inner ear. Because the symptoms and organs involved vary widely and the disease comes and goes, diagnosis is difficult, which can lead to serious organ damage and health problems. Researchers aim to better understand how RP develops and behaves over time. This research is an observational study that follows people diagnosed with RP over time to study the diseases progression and underlying causes. Participants will have study visits every 6 or 12 months to provide blood and urine samples, undergo physical exams, and share their medical and medication history. They will also complete questionnaires about their disease activity, health, and lifestyle factors like tobacco, alcohol, and drug use. Participants will be involved in regular assessments for up to 36 months, with data collected to evaluate the course and immune mechanisms of RP. The study will use questionnaires called PROMIS at multiple timepoints to assess health status. This approach aims to generate new insights into RP that may help develop better diagnostic methods and treatments in the future. The University of Pennsylvania is leading this multicenter study.

Longitudinal Study for Relapsing Polychondritis