Actively Recruiting
Longitudinal Study for Relapsing Polychondritis
Led by University of Pennsylvania · Updated on 2026-01-23
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Relapsing polychondritis (RP) is a rare inflammatory disease that causes recurring inflammation of the cartilage in areas like the ears, nose, airways, chest wall, and joints. It can also affect other parts such as the eyes, blood vessels, nervous system, skin, and inner ear. Because the symptoms and organs involved vary widely and the disease comes and goes, diagnosis is difficult, which can lead to serious organ damage and health problems. Researchers aim to better understand how RP develops and behaves over time. This research is an observational study that follows people diagnosed with RP over time to study the disease's progression and underlying causes. Participants will have study visits every 6 or 12 months to provide blood and urine samples, undergo physical exams, and share their medical and medication history. They will also complete questionnaires about their disease activity, health, and lifestyle factors like tobacco, alcohol, and drug use. Participants will be involved in regular assessments for up to 36 months, with data collected to evaluate the course and immune mechanisms of RP. The study will use questionnaires called PROMIS at multiple timepoints to assess health status. This approach aims to generate new insights into RP that may help develop better diagnostic methods and treatments in the future. The University of Pennsylvania is leading this multicenter study.
CONDITIONS
Brief Title
Longitudinal Study for Relapsing Polychondritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any subject considered to have a diagnosis of relapsing polychondritis according to the investigator.
You will not qualify if you...
- Inability to provide consent, or in the case of minors, assent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 36 months
Participants attend visits every 6 months or annually for assessments including blood and urine collection, physical exams, medical and medication history, and questionnaires to evaluate disease activity and health status.
Visits occur every 6 months or annually
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
C
Carol McAlear
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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