LUNG INFECTION in ICU

What this Trial Is About

Researchers are studying patients in intensive care units (ICU) who have lung infections, specifically focusing on ventilator-associated pneumonia (VAP). The study aims to understand the differences in immune cells, especially alveolar macrophages and neutrophils, found in blood and lung fluid after an infection. This observational study is designed to explore immune cell patterns before and at the time VAP is diagnosed, providing insights into how the immune system responds during severe lung infections in critically ill patients. The study does not involve experimental treatments but observes patients who meet specific severe illness criteria, such as septic shock from pneumonia or other causes, severe trauma, or major burns. Participants must be adults aged 18 or older, hospitalized in ICU with these conditions, and show certain clinical signs like vasopressor use and organ dysfunction scores. The research focuses on collecting and analyzing samples to measure immune cells in blood and bronchoalveolar lavage (BAL) fluid during the infection period. Participants will undergo assessments that include sampling of blood and BAL fluid to study immune cell patterns related to VAP. The main outcome measured is the immune cell profiles before and at the time of VAP diagnosis. The study involves monitoring these immune responses in severely ill ICU patients, with participation lasting through the infection and diagnosis period. Safety monitoring and consent processes are in place, and the study will continue through June 2027.

LUNG INFECTION in ICU (LUNG-I3)