Actively Recruiting
Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
Led by Charles University, Czech Republic · Updated on 2024-07-26
160
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
HyPerMICROBE is a single-centre, controlled, randomised, prospective, superiority clinical trial to compare the efficacy of daily oral care with 3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine digluconate) on the cumulative incidence of lower respiratory tract microbial colonisation in mechanically ventilated adult critically ill patients.
CONDITIONS
Official Title
Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient admitted to ICU with expected stay longer than 5 days
- Currently on mechanical ventilation or expected to need it for at least 72 hours
- Clinical Pulmonary Infection Score (CPIS) less than 6 at baseline
- No history or symptoms of aspiration at baseline
You will not qualify if you...
- Receiving antibiotic therapy for respiratory infection on admission
- Suspected pulmonary infection at admission or within first 48 hours of mechanical ventilation
- Pregnant
- Presence of oral ulcers or injuries
- Known allergy to hydrogen peroxide
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
3rd Faculty of Medicine and FNKV
Prague, Czechia, 11000
Actively Recruiting
Research Team
K
Kateřina Rambousková, MD
CONTACT
A
Adela Jiroudkova
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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