Study of Magnesium Sulfate Effects on Blood Clotting After Laparoscopic Gynecological Surgery Under General Anesthesia

What this Trial Is About

Researchers are investigating the effects of magnesium sulfate on postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia. This randomized, double-blind, controlled study aims to assess how magnesium sulfate influences blood clotting using thromboelastometry, a method that measures clotting time and clot formation parameters. The study compares magnesium sulfate with a placebo to understand its potential impact on postoperative blood coagulation. Participants are randomly assigned to one of two groups. One group receives an intravenous bolus of magnesium sulfate followed by a continuous infusion during surgery. The other group receives an equivalent volume of normal saline as a placebo. Blood coagulation parameters are measured before and after magnesium sulfate or placebo administration using thromboelastometry, with assessments done intraoperatively and in the post-anesthesia care unit. During the study, patients undergo blood coagulation tests including clotting time, clot formation time, maximum clot firmness, and a-angle measurements. Additional monitoring includes assessments of coagulation markers such as INR, aPTT, PT, platelet count, and fibrinogen levels before surgery and up to six hours afterward. Clinical thrombosis symptoms are also observed for 24 hours after surgery. The study plans to track these measures closely to evaluate the effects of magnesium sulfate on postoperative blood clotting.

Magnesium Sulfate and Postoperative Hypercoagulability in Laparoscopic Gynecological Surgeries