Actively Recruiting

Age: 18Years - 55Years
MALE
ID05514223

Measuring Free Radicals With Diamond Magnetometry in Human Single Sperm Cells Related to Microbiota and Lifestyle Factors

Led by University Medical Center Groningen · Updated on 2026-05-08

80

Participants Needed

1

Research Sites

39 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating male infertility, focusing on how free radicals in sperm and blood may affect semen quality. The study explores the use of a new technique called diamond magnetometry to measure free radicals directly on single sperm cells and in serum. It also examines how the composition of bacteria in semen and lifestyle factors like diet and smoking might influence free radical levels and sperm health. Participants are males aged 18 to 55 years who are visiting a reproductive medicine center for standard semen analysis. Semen and blood samples will be collected to measure free radicals using diamond magnetometry and other biochemical methods. The study will analyze semen microbiota using genetic sequencing and assess lifestyle and food intake through questionnaires. These measurements aim to connect free radical levels with semen quality, bacterial composition, and lifestyle. During the study, participants will provide semen and blood samples on the same day. Researchers will perform real-time assessments of free radicals in sperm and serum and analyze semen bacteria species and abundance. They will also measure markers like malondialdehyde and free thiols in blood serum. Lifestyle questionnaires and food frequency surveys will be used to gather additional data. The study outcomes focus on understanding the relationships between free radicals, microbiota, semen parameters, and lifestyle, with follow-up over about one year.

CONDITIONS

Brief Title

Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors

Who Can Participate

Age: 18Years - 55Years
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Males of couples visiting the Center for Reproductive Medicine between 18 and 55 years old
  • Planned semen analysis as part of standard care
Not Eligible

You will not qualify if you...

  • Males who have received chemotherapy or radiotherapy
  • Males who have used testosterone supplements or anabolic steroids
  • Males diagnosed with azoospermia
  • Males with abnormal semen analysis due to genetic causes
  • Semen analysis showing round cells greater than 2 million per milliliter as a marker for infection
  • Males currently using antibiotics

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Baseline and up to 1 year

Participants provide semen and blood samples for analysis of free radicals, seminal microbiota, and oxidative stress markers. Lifestyle factors and food intake information are collected through questionnaires.

1 baseline visit with sample collection; additional data collected via questionnaires over 1 year

Trial Site Locations

Total: 1 location

1

University Medical Centre Groningen

Groningen, Provincie Groningen, Netherlands, 9713GZ

Actively Recruiting

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Research Team

A

Astrid EP Cantineau, Dr.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality.

Shun-Long Weng, Chih-Min Chiu, Feng-Mao Lin...

https://pubmed.ncbi.nlm.nih.gov/25340531

Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach.

Marie E Thoma, Alexander C McLain, Jean Fredo Louis...

https://pubmed.ncbi.nlm.nih.gov/23290741