Actively Recruiting
Microparticles Blood Level in Acute Carbon Monoxide Poisoning
Led by Azienda Ospedaliero Universitaria Maggiore della Carita · Updated on 2024-11-14
108
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
A
Azienda Ospedaliero Universitaria Maggiore della Carita
Lead Sponsor
U
Università degli Studi del Piemonte Orientale Amedeo Avogadro
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to investigate whether there is an increase in circulating microparticles in the blood of patients with acute carbon monoxide (CO) poisoning compared to healthy individuals. The study explores the complex effects of CO poisoning beyond oxygen deprivation, including inflammation and long-term neurological risks. Researchers want to understand the relationship between CO poisoning severity and microparticle levels, as well as identify risk factors for delayed neurological syndrome. The study involves patients who require hyperbaric oxygen treatment for acute CO poisoning and a control group of healthy volunteers assisting in the hyperbaric chamber. Blood samples are collected from patients before and after the hyperbaric oxygen treatment to measure microparticle levels using specialized laboratory techniques. Healthy controls provide comparative data to evaluate differences in microparticles between poisoned and non-poisoned individuals. Participants will have blood drawn at two time points during the treatment and complete a mental status questionnaire at the start and 45 days later to check for delayed neurological effects. The research will analyze microparticles and their types, and follow participants for up to two years to study proteomic and transcriptomic outcomes. This comprehensive approach helps assess the biological impact of CO poisoning and monitor neurological health over time.
CONDITIONS
Brief Title
Microparticles Blood Level in Acute Carbon Monoxide Poisoning
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Acute carbon monoxide poisoning
- Need for treatment with hyperbaric oxygen
You will not qualify if you...
- Patient reject to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - At treatment day
Participants provide blood samples before and after hyperbaric oxygen treatment to measure circulating microparticles and complete a mental status questionnaire.
2 visits (in-person) on the treatment day: before and after hyperbaric oxygen therapy
Duration - 45 days
Participants complete a follow-up mental status evaluation by phone to assess delayed neurological syndrome.
1 follow-up visit (phone call) 45 days after intoxication
Trial Site Locations
Total: 1 location
1
AOU Maggiore della Carità
Novara, Italy, 28100
Actively Recruiting
Research Team
R
Rosanna Vaschetto
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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