Study of Microparticle Levels in Blood of Adults With Acute Carbon Monoxide Poisoning Compared to Healthy Volunteers

What this Trial Is About

This research aims to investigate whether there is an increase in circulating microparticles in the blood of patients with acute carbon monoxide CO poisoning compared to healthy individuals. The study explores the complex effects of CO poisoning beyond oxygen deprivation, including inflammation and long-term neurological risks. Researchers want to understand the relationship between CO poisoning severity and microparticle levels, as well as identify risk factors for delayed neurological syndrome. The study involves patients who require hyperbaric oxygen treatment for acute CO poisoning and a control group of healthy volunteers assisting in the hyperbaric chamber. Blood samples are collected from patients before and after the hyperbaric oxygen treatment to measure microparticle levels using specialized laboratory techniques. Healthy controls provide comparative data to evaluate differences in microparticles between poisoned and non-poisoned individuals. Participants will have blood drawn at two time points during the treatment and complete a mental status questionnaire at the start and 45 days later to check for delayed neurological effects. The research will analyze microparticles and their types, and follow participants for up to two years to study proteomic and transcriptomic outcomes. This comprehensive approach helps assess the biological impact of CO poisoning and monitor neurological health over time.

Microparticles Blood Level in Acute Carbon Monoxide Poisoning