Mortality Risks and Causes in Previous Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study.
Gyo J Ahn, Solam Lee, Yeon-Woo Heo...
https://pubmed.ncbi.nlm.nih.gov/39298511Actively Recruiting
All Genders
ID04490317
CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
Led by Wonju Severance Christian Hospital · Updated on 2024-07-23
1500
Participants Needed
1
Research Sites
260 weeks
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying patients who have experienced carbon monoxide (CO) poisoning to understand how different treatments affect their recovery. This observational study aims to evaluate the effects of therapies such as hyperbaric oxygen therapy (HBO), therapeutic hypothermia (TH), and other drugs on short- and long-term outcomes. The study also investigates brain and heart complications caused by CO poisoning and how these complications relate to patient prognosis. Participants diagnosed with acute CO poisoning will undergo various assessments, including cardiac MRI, cardiac CT, transthoracic echocardiography (TTE), brain MRI, neurocognitive function tests, and laboratory tests. Treatments such as HBO and TH are used as part of medical care and monitored throughout the study. The study focuses on tracking responses to these treatments and the development of neurocognitive and psychological effects over time. During the study, subjects are regularly monitored by physicians. Evaluations occur at several time points including 1 month, 6 months, 12 months, and up to 5 years after CO exposure. Researchers measure therapeutic responses, brain and heart injuries, neurocognitive function, psychological outcomes, and mortality. The study collects detailed imaging and laboratory data to understand complications and their impact on recovery, with ongoing follow-up to capture both immediate and long-term effects.
CONDITIONS
Brief Title
CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- Acute carbon monoxide poisoning
You will not qualify if you...
- Declined to enrollment in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Within 1 month after carbon monoxide exposure
Participants undergo diagnostic tests including cardiac MRI, cardiac CT, transthoracic echocardiogram (TTE), brain MRI, neurocognitive function tests, and laboratory tests to evaluate brain and heart complications related to carbon monoxide poisoning.
1 to 2 visits depending on tests performed
Monitoring
Duration - Up to 5 years after carbon monoxide exposure
Participants are regularly monitored by physicians to assess therapeutic effects of treatments such as hyperbaric oxygen therapy and therapeutic hypothermia, and to evaluate short- and long-term outcomes including neurocognitive sequelae and mortality.
Regular visits over 5 years for follow-up assessments including neurocognitive tests and imaging studies
Trial Site Locations
Total: 1 location
1
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea, 26426
Actively Recruiting
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Research Team
Y
Yong Sung Cha, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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