Actively Recruiting
Mode of Exercise and Bone Biomarkers in Older Veterans
Led by VA Office of Research and Development · Updated on 2025-06-05
120
Participants Needed
1
Research Sites
247 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
U
University of Colorado, Denver
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
CONDITIONS
Official Title
Mode of Exercise and Bone Biomarkers in Older Veterans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy Veterans aged 60 years or older
- Men and women living in the Denver Metro Area
- Normally active with regular activities like walking or recreational cycling
You will not qualify if you...
- Kidney problems with an eGFR below 60 mL/min/1.73m2
- Liver disease with elevated liver enzymes (AST, ALT) over 1.5 times normal
- Thyroid hormone imbalance with TSH below 0.5 or above 5.0 mU/L
- Abnormal blood calcium levels below 8.5 or above 10.3 mg/dL
- Low vitamin D levels below 20 ng/mL
- Uncontrolled high blood pressure with systolic over 150 mmHg or diastolic over 90 mmHg
- History of type 1 or type 2 diabetes
- Heart disease or serious irregular heart rhythms
- Anemia with hemoglobin less than 12.1 g/dL for women or less than 14.3 g/dL for men
- Bone fracture within the past 6 months
- Current COVID-19 diagnosis or symptoms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Colorado, United States, 80045-7211
Actively Recruiting
Research Team
S
Sarah J Wherry, PhD
CONTACT
T
Toby Wellington, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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