Actively Recruiting
Exploring the Molecular and Cellular Composition of Uterine Lavage Specimens Collected During Gynecologic Surgery
Led by Stanford University · Updated on 2025-11-05
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the clinical and technical feasibility of using a new uterine lavage collection catheter to gather uterine lavage samples from up to 50 individuals undergoing gynecologic surgery. The study aims to describe the cellular composition of these samples, focusing on those with gynecologic cancer, uterine cancer, or other gynecologic diseases. This is a prospective cohort study enrolling participants consecutively to assess this novel procedure. All participants will undergo uterine lavage collection during their scheduled gynecologic surgery. Saline will be introduced into the uterine cavity and then retrieved to collect cells and fluid for molecular and cellular analysis. The study involves a single experimental group where all enrolled participants receive this uterine lavage procedure intraoperatively. Participants will be involved during their surgery when the uterine lavage fluid is collected. Researchers will characterize the cellular composition of the lavage fluid and perform molecular profiling and detection of inflammatory biomarkers at the time of surgery. The study will monitor these outcomes during the surgical procedure, with no long-term follow-up mentioned. Participation is expected to last through the surgical event and sample analysis.
CONDITIONS
Brief Title
Molecular and Cellular Profiling of Uterine Lavage Collected During Gynecologic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing gynecologic surgery with Stanford Healthcare
- Intact uterus and cervix
- At least one intact fallopian tube and ovary on the same side
- Aged 18 years or older
- Ability to understand and willingness to provide written informed consent
You will not qualify if you...
- Known endometrial or cervical cancer or endometrial or cervical intraepithelial neoplasia
- Status post bilateral salpingectomy or tubal ligation
- Lack of consenting capacity
- Positive preoperative pregnancy test
- Active uterine bleeding (e.g., menses)
- Intrauterine device in place
- Non-English speaking (requires interpreter)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - At time of surgery
During gynecologic surgery, saline is introduced into the uterine cavity and retrieved to collect cells and fluid for molecular and cellular analyses.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
R
Rozelle Laquindanum
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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