Studying Cells and Molecules in Uterine Lavage Fluid During Gynecologic Surgery

What this Trial Is About

Researchers are evaluating the clinical and technical feasibility of using a new uterine lavage collection catheter to gather uterine lavage samples from up to 50 individuals undergoing gynecologic surgery. The study aims to describe the cellular composition of these samples, focusing on those with gynecologic cancer, uterine cancer, or other gynecologic diseases. This is a prospective cohort study enrolling participants consecutively to assess this novel procedure. All participants will undergo uterine lavage collection during their scheduled gynecologic surgery. Saline will be introduced into the uterine cavity and then retrieved to collect cells and fluid for molecular and cellular analysis. The study involves a single experimental group where all enrolled participants receive this uterine lavage procedure intraoperatively. Participants will be involved during their surgery when the uterine lavage fluid is collected. Researchers will characterize the cellular composition of the lavage fluid and perform molecular profiling and detection of inflammatory biomarkers at the time of surgery. The study will monitor these outcomes during the surgical procedure, with no long-term follow-up mentioned. Participation is expected to last through the surgical event and sample analysis.

Molecular and Cellular Profiling of Uterine Lavage Collected During Gynecologic Surgery