Observational Study on Premature Ovarian Insufficiency Understanding Its Development and Health Effects in Women

What this Trial Is About

Premature ovarian insufficiency POI occurs when ovarian function declines in women before age 40, significantly affecting health and quality of life. This research aims to better understand the causes, progression, and health impacts of POI, as well as evaluate hormone replacement therapy HRT options. The study will create a hospital-based, multi-center case-control and prospective cohort to gather comprehensive data on POIs natural course and effects. The study includes several groups women diagnosed with POI, control women with regular menstrual cycles, those scheduled for ovarian surgery, and those undergoing oophorectomy. Participants provide biological samples, lifestyle and health information, and undergo long-term follow-up assessments. Data collection spans multiple health factors including reproductive hormones, bone density, psychological well-being, and metabolic markers. Participants will be monitored at regular intervals up to 36 months with tests such as bone density scans, hormone level checks, blood glucose and insulin measurements, and psychological assessments for anxiety and depression. The study also tracks symptoms related to low estrogen and sexual health. Safety and health outcomes are observed through blood counts, liver and kidney function tests, and ultrasound exams. This comprehensive approach aims to deepen understanding and support improved care for women with POI.

A Multicenter Observational Study on the Development and Health Effects of Premature Ovarian Insufficiency