Observational Study on Ovarian Function and Serum Biomarkers in Women Aged 18 to 45

What this Trial Is About

Researchers are investigating differences in serum biomarkers among women with different ovarian functions, including those with diminished ovarian reserve, premature ovarian insufficiency, and normal ovarian function. This observational study aims to understand how these biomarkers correlate with ovarian health by comparing affected women to those with normal menstruation and hormone levels. The study involves collecting blood samples from women in three groups those with diminished ovarian reserve, those with premature ovarian insufficiency, and healthy controls with regular menstruation. The blood tests will measure levels of copper ions, iron ions, ceruloplasmin, CuZn superoxide dismutase, and malondialdehyde, among other related biomarkers associated with copper and iron metabolism and oxidative stress. Participants will provide blood samples during the 2nd to 4th day of their menstrual cycle or during the enrolled week for amenorrhea patients. Researchers will analyze these samples to assess the biomarkers and evaluate ovarian function. The study involves informed consent and includes women aged 18 to 45, with some groups having specific hormone level criteria. The trial will continue until November 2025, with data collected to better understand ovarian aging and function.

The Correlation Between Ovarian Function and Serum Biomarkers