Magnetic resonance elastography for evaluation of renal parenchyma in chronic kidney disease: a pilot study.
Jun Hee Han, Jhii-Hyun Ahn, Jae-Seok Kim
https://pubmed.ncbi.nlm.nih.gov/32367323Actively Recruiting
Age: 18Years - 65Years
All Genders
Healthy Volunteers
ID06202235
Multifrequency Renal MR Elastography in Evaluation of Chronic Kidney Diseases: Can Shear Stiffness Evaluate Renal Fibrosis in GFR-normal Patients?
Led by Shengjing Hospital · Updated on 2026-02-10
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic Kidney Disease (CKD) affects about 10% of people worldwide and can lead to serious outcomes like death or the need for kidney replacement therapy. Kidney fibrosis, or scarring, is a key factor in how CKD progresses. This research focuses on using multifrequency Magnetic Resonance Elastography (MRE), a noninvasive imaging method that measures tissue stiffness, to better understand kidney fibrosis, especially in early CKD stages when kidney function may still appear normal. Participants include adults with CKD and healthy volunteers without kidney disease. Both groups will undergo the same detailed MRI scans, including MRE and other advanced imaging techniques, to assess kidney tissue properties. CKD patients will have their MRI within 7 days of a kidney biopsy and will also have blood tests and blood pressure measured. Healthy volunteers serve as a comparison group to establish baseline imaging values. During the study, participants will undergo various imaging sessions and blood tests to track kidney health and fibrosis. Researchers will measure changes in kidney filtration rate over 24 months as the main outcome. This study will also explore how combined MRI techniques might predict CKD progression. Participation includes follow-up and monitoring over time to collect these important kidney health data.
CONDITIONS
Brief Title
Multifrequency MRE in Evaluation of Chronic Kidney Diseases
Who Can Participate
Age: 18Years - 65Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years with Chronic Kidney Disease defined by 2024 KDIGO guidelines
- Elevated serum creatinine or abnormal proteinuria
- Renal MRI performed within 7 days of renal biopsy
- Age-matched healthy individuals with no known kidney disease (for control group)
You will not qualify if you...
- History of genitourinary malignancy, polycystic kidney disease, renal transplantation, or acute renal failure
- Contraindications to MRI examination
- Poor quality MRI images
- Kidney deformity or severe hydronephrosis seen on MRI
- Poorly defined corticomedullary demarcation on MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Within 7 days of renal biopsy for CKD patients; timing for healthy volunteers as scheduled
Participants undergo comprehensive MRI scans including Magnetic Resonance Elastography and other functional MRI techniques to evaluate kidney and liver characteristics. For CKD patients, MRI is performed within 7 days of their renal biopsy, and blood tests along with blood pressure measurements are collected.
1 to 2 visits depending on participant group and biopsy timing
Long-term Monitoring
Duration - 24 months
Participants are monitored over 24 months to assess the annual rate of decline in kidney function (eGFR) through follow-up evaluations.
Follow-up visits as scheduled during the 24-month period
Trial Site Locations
Total: 1 location
1
Shengjing Hospital of China Medical University
Shenyang, Liaoning, China, 110004
Actively Recruiting
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Research Team
Y
yu shi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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