Using Multifrequency Magnetic Resonance Elastography to Detect Kidney Fibrosis in Adults with Early Chronic Kidney Disease

What this Trial Is About

Chronic Kidney Disease CKD affects about 10% of people worldwide and can lead to serious outcomes like death or the need for kidney replacement therapy. Kidney fibrosis, or scarring, is a key factor in how CKD progresses. This research focuses on using multifrequency Magnetic Resonance Elastography MRE, a noninvasive imaging method that measures tissue stiffness, to better understand kidney fibrosis, especially in early CKD stages when kidney function may still appear normal. Participants include adults with CKD and healthy volunteers without kidney disease. Both groups will undergo the same detailed MRI scans, including MRE and other advanced imaging techniques, to assess kidney tissue properties. CKD patients will have their MRI within 7 days of a kidney biopsy and will also have blood tests and blood pressure measured. Healthy volunteers serve as a comparison group to establish baseline imaging values. During the study, participants will undergo various imaging sessions and blood tests to track kidney health and fibrosis. Researchers will measure changes in kidney filtration rate over 24 months as the main outcome. This study will also explore how combined MRI techniques might predict CKD progression. Participation includes follow-up and monitoring over time to collect these important kidney health data.

Multifrequency MRE in Evaluation of Chronic Kidney Diseases