Study of Muscle and Bone Changes in Adults Aged 40 to 70 with Type 2 Diabetes and Diabetic Neuropathy Compared to Healthy Adults

What this Trial Is About

Researchers are investigating muscle fiber type differences in people with type 2 diabetes mellitus T2DM, focusing on those with diabetic peripheral neuropathy DNP, a common complication. The study compares muscle and nerve function, inflammation, cellular energy use, and blood vessel health among three groups T2DM patients with DNP, T2DM patients without DNP, and healthy individuals matched by age and sex. The main question is whether muscle fiber types vary among these groups. Participants will undergo several evaluations including electromyoneurography EMNG to assess nerve function, blood tests to measure insulin, blood sugar, lipids, and inflammation, and muscle biopsies of the calf muscle to examine muscle structure. Additional tests include functional muscle strength and power assessments through jumping and chair rise tests mechanography, a calf scan using peripheral Quantitative Computed Tomography pQCT for muscle and bone density, and a 15-minute resting electrocardiogram ECG. Questionnaires will gather information on diet, physical activity, smoking, alcohol use, and medical history. During the study, participants will have their height, weight, and hip-to-waist ratio measured. Researchers will analyze differences in muscle fiber composition, nerve conduction velocity, muscle and bone density, mitochondrial function, physical activity levels, and lifestyle factors at enrollment. The study is observational and involves no treatment. The total participation time varies but includes all listed assessments at enrollment. The research is led by University Hospital, Ghent.

Muscle and Bone in Patients with Diabetes Mellitus and Neuropathy