Actively Recruiting
Muscle-tendon Pathology and Metabolic Dysregulation in CP
Led by University of Graz · Updated on 2026-04-29
50
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
Sponsors
U
University of Graz
Lead Sponsor
M
Medical University of Graz
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation. Furthermore, it will be investigated whether there are associations between the existing pathophysiology as well as inactivity and muscle function, cardiometabolic risk factors and inflammation. Moreover, the potential of the target group for adaptation of its muscular, cardiorespiratory, and endocrine system will be investigated. The study parameters will be determined in adolescents and young adults aged 14 to 30 years with moderate to severe spastic cerebral palsy and compared with those of their less severely affected and healthy peers (cross-sectional study). In addition, the more affected individuals will participate in a 12-week training intervention (longitudinal study) performed with special tricycles (i.e., Frame Runners). To measure the study parameters, ultrasound, strength tests, near-infrared spectroscopy, blood analyses, and spiroergometry will be used. The fitness training will be performed two times a week for 12 weeks with the Frame Runners.
CONDITIONS
Official Title
Muscle-tendon Pathology and Metabolic Dysregulation in CP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of spastic cerebral palsy
- Mildly, moderately, or severely affected (Gross Motor Function Classification System level I-IV)
- Age between 14 and 30 years
- Ability to understand and follow verbal instructions
- Strong communication skills
- Sufficient vision for safe movement around people and obstacles
- Less than 15 hours experience with Frame Runners; healthy peers in the same age range
You will not qualify if you...
- Other forms of cerebral palsy
- Orthopaedic surgery within the last 12 months
- Botulinum toxin treatment within the last 6 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Institute of Human Movement Science, Sport and Health, University of Graz
Graz, Austria, 8010
Actively Recruiting
Research Team
A
Annika Kruse, Dr.
CONTACT
M
Martin Svehlik, Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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