Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation A Three-Dimensional Echocardiographic Study (TRICUSPID-AF)

What this Trial Is About

This research aims to understand how the tricuspid valve changes in patients with atrial fibrillation (AF) who do not have significant tricuspid regurgitation (TR). The study focuses on patients with paroxysmal or persistent AF and looks at how the burden of AF affects tricuspid valve remodeling over time. Results will be compared to control groups including people without AF and those with moderate atrial functional TR and AF but no significant left-sided valve disease or previous valve surgery. Participants with paroxysmal or persistent AF who are scheduled for transthoracic echocardiography (TTE) before AF ablation will be enrolled. They will have 3D imaging of the tricuspid valve and undergo repeat TTE one year later. The study uses an AI-powered 3D tool to analyze the tricuspid valve geometry. AF burden will be monitored through Holter ECG at baseline, 3 months, and 12 months. The study includes control groups with normal hearts or with moderate atrial functional TR and AF. During the study, participants will have TTE scans to measure tricuspid annular geometry and strain analysis of right heart chambers. Holter ECG will track the AF burden. The primary outcome is the difference in 3D tricuspid annular geometry between paroxysmal and persistent AF after 12 months. Secondary outcomes include changes in valve geometry, development of moderate or worse TR, and the relationship between AF burden and valve remodeling. The study will follow participants for at least one year without additional interventions.

Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study