Actively Recruiting
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Led by Massachusetts General Hospital · Updated on 2025-08-12
100
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.
CONDITIONS
Official Title
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of HPV-associated Recurrent Respiratory Papillomatosis
- Has pulmonary lesions
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale School of Medicine
New Haven, Connecticut, United States, 06520
Actively Recruiting
Research Team
S
Sara Pai, MD, PhD
CONTACT
M
Marcelle Stiff
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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