Study of Autoimmune Atrophic Gastritis Natural History, Progression, and Clinical Features

What this Trial Is About

Researchers are studying autoimmune atrophic gastritis AAG, an immune disorder that causes loss of stomach glands and mucosal thinning. This condition can lead to nutrient absorption problems, especially vitamin B12 deficiency, which affects various body systems and may cause serious complications including gastric cancer. Despite its impact, little is known about its frequency and progression, prompting this study to better understand the diseases natural course and complications. The study observes patients diagnosed with AAG based on specific biopsy criteria. No experimental treatments are given since this is an observational study. Patients will be assessed at baseline, six months, and twelve months to monitor symptoms using a visual scale and to collect laboratory data. The goal is to clarify disease progression and identify early signs to prevent irreversible issues. Participants will undergo evaluations including symptom assessments and lab tests at the scheduled visits. Researchers will monitor changes in symptoms and disease markers over time. The primary measure is to document the natural history and epidemiology of AAG to improve early diagnosis and prevention. The study is led by Fondazione IRCCS Policlinico San Matteo di Pavia and will continue through 2026.

Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis