Actively Recruiting
Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2026-02-05
600
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying autoimmune atrophic gastritis (AAG), an immune disorder that causes loss of stomach glands and mucosal thinning. This condition can lead to nutrient absorption problems, especially vitamin B12 deficiency, which affects various body systems and may cause serious complications including gastric cancer. Despite its impact, little is known about its frequency and progression, prompting this study to better understand the disease's natural course and complications. The study observes patients diagnosed with AAG based on specific biopsy criteria. No experimental treatments are given since this is an observational study. Patients will be assessed at baseline, six months, and twelve months to monitor symptoms using a visual scale and to collect laboratory data. The goal is to clarify disease progression and identify early signs to prevent irreversible issues. Participants will undergo evaluations including symptom assessments and lab tests at the scheduled visits. Researchers will monitor changes in symptoms and disease markers over time. The primary measure is to document the natural history and epidemiology of AAG to improve early diagnosis and prevention. The study is led by Fondazione IRCCS Policlinico San Matteo di Pavia and will continue through 2026.
CONDITIONS
Brief Title
Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, age 9 years or older
- Diagnosis of autoimmune atrophic gastritis according to the updated Sydney System criteria at a specialized outpatient clinic
- Signed written informed consent
You will not qualify if you...
- Uncertain histopathological findings
- Persistent or active Helicobacter pylori infection
- Long-term proton pump inhibitor use and presence of atrophic pangastritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline and 12 months
Participants diagnosed with autoimmune atrophic gastritis are evaluated and undergo required laboratory tests.
1 baseline visit and 1 final evaluation visit at 12 months
Duration - 6 months
Participants are monitored for symptoms associated with autoimmune atrophic gastritis and assessed using the VAS scale.
1 visit at 6 months
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo, SC Medicina Generale 1
Pavia, Pavia, Italy, 27100
Actively Recruiting
Research Team
E
Emanuela Miceli, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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