Knee osteoarthritis: Current status and research progress in treatment (Review).
Ruizhi Geng, Jiayi Li, Chen Yu...
https://pubmed.ncbi.nlm.nih.gov/37745043/Actively Recruiting
Led by Tanta University · Updated on 2026-10-06
80
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating two different techniques of genicular nerve block to manage pain and improve quality of life in people with Knee Osteoarthritis KOA, a condition where the knee joint cartilage and bone break down. The study compares the commonly used 3-needle protocol targeting three specific genicular nerves with a newer 5-needle approach designed to block additional sensory nerve branches for potentially better pain relief. Participants will be randomly assigned to receive either the 3-needle or the 5-needle genicular nerve block. These nerve blocks are injections aimed at reducing knee pain by targeting nerves around the knee joint. Both groups will be monitored to assess their pain levels, quality of life, opioid medication use, and patient satisfaction over a period of six months after treatment. During the study, participants will undergo evaluations to measure changes in their knee pain and quality of life at six months post-treatment. Researchers will also track the use of opioid pain medications and overall satisfaction with the procedures. The study is double-blinded, meaning neither participants nor researchers know which treatment is given to ensure unbiased results. The entire participation lasts through six months of follow-up after the nerve block treatment.
CONDITIONS
3-Needle vs 5-Needle of Genicular Nerve Block on Pain and Quality of Life in Knee Osteoarthritis
M
Mohammed S Elsharkawy, MD
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Tanta University
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment with follow-up over 6 months
Participants receive either the 3-needle or 5-needle genicular nerve block injection to target nerves around the knee.
Follow-up visits for assessments up to 6 months
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Ruizhi Geng, Jiayi Li, Chen Yu...
https://pubmed.ncbi.nlm.nih.gov/37745043/Tanta University
Lead Sponsor