Actively Recruiting
New Perspectives in Adenomyosis Pathogenesis With Epigenetic Analysis and miRNAs
Led by Université Catholique de Louvain · Updated on 2024-04-22
50
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research aims to identify differences in circulating microRNAs (miRNAs) in the blood of women with adenomyosis to develop new, noninvasive diagnostic methods. Building on previous findings that miRNAs are abnormally expressed in conditions like endometriosis, this study will compare miRNA expression between patients with adenomyosis and healthy subjects to find potential diagnostic biomarkers. Blood samples will be collected from 50 pre-menopausal women undergoing gynecological surgery, including 25 diagnosed with adenomyosis and 25 without endometrial-related diseases. A single 10 ml blood sample will be taken on the day of surgery, processed to isolate miRNAs using specialized kits, and analyzed using commercial arrays and RT-qPCR to measure expression of around 1000 miRNAs. The study will also investigate the biological functions affected by differentially expressed miRNAs. Participants will have their blood drawn during surgery for sample analysis. Researchers will examine miRNA levels as diagnostic biomarkers throughout the study, which lasts approximately 6.5 years. Samples will be stored carefully, and data will be analyzed to identify miRNAs distinguishing adenomyosis patients from healthy individuals. The findings could support the development of new diagnostic tools or treatments for adenomyosis.
CONDITIONS
Brief Title
New Perspectives in Adenomyosis Pathogenesis With Epigenetic Analysis and miRNAs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years
- Female and pre-menopausal
You will not qualify if you...
- Tested positive for HIV or Hepatitis
- Participated in another clinical study in the past 12 months
- Have symptoms of endometriosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide a single blood sample on the day of their scheduled surgical intervention for analysis of circulating miRNAs as potential diagnostic biomarkers.
1 visit (in-person)
Duration - Approximately 6.5 years
Participants' circulating miRNA levels are analyzed over the course of the study to identify diagnostic biomarkers of adenomyosis.
No additional visits required
Trial Site Locations
Total: 1 location
1
CUSL
Brussels, Woluwe-Saint-Lambert, Belgium, 1200
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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