Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID06491667

Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein as Cost-Effective Prognostic Markers in ST-Elevation Myocardial Infarction

Led by Sohag University · Updated on 2024-07-09

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Acute myocardial infarction (AMI), commonly known as a heart attack, is a serious and often fatal emergency and is the leading cause of death worldwide. The condition mainly results from atherosclerosis, a long-term buildup of plaques in the coronary arteries, which involves complex immune and inflammatory processes. Researchers are interested in studying inflammatory markers to better understand and predict outcomes in ST-segment elevation myocardial infarction (STEMI). This study focuses on two relatively inexpensive markers, the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP), which may help assess cardiovascular risk and prognosis, especially in low-resource settings. This observational study evaluates the role of NLR and CRP levels as diagnostic tests in patients with STEMI. Participants are grouped based on whether they have elevated or normal levels of these markers. The study tracks these markers over six months to explore their predictive value for immediate and short-term prognosis after STEMI. The research involves measuring these inflammatory markers at admission and during follow-up. Participants will undergo blood tests to measure NLR and CRP and will be monitored for six months to assess their cardiovascular outcomes. Researchers will review these markers to determine their relationship with complications after STEMI. The study aims to provide cost-effective tools for risk stratification and prognosis in acute myocardial infarction. Participation involves regular follow-ups and blood sample collection to monitor the markers and health status over the study period.

CONDITIONS

Brief Title

NLR AND CRP Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 years or older of either sex
  • Diagnosed with ST-segment elevation myocardial infarction (STEMI) by increased serum cardiac biomarkers or ECG
Not Eligible

You will not qualify if you...

  • Patients with non-ST elevation myocardial infarction (NSTEMI) or unstable angina
  • Presence of inflammatory conditions such as collagen-vascular disorders
  • Acute or chronic infectious diseases
  • Autoimmune or neoplastic diseases
  • Chronic liver disease
  • Renal failure
  • Thyroid disorders
  • Previous valvular heart disease

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - At baseline

Participants undergo blood tests to measure neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels for prognostic assessment of ST-elevation myocardial infarction.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 6 months

Participants are observed to assess the predictive value of NLR and CRP levels on myocardial infarction outcomes over time.

Follow-up visits as needed for outcome assessment

Trial Site Locations

Total: 1 location

1

Sohag university hospital

Sohag, Egypt

Actively Recruiting

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Research Team

A

Albair Y Kaiser, Resident

S

Sharaf El-DEEN Sh Abd-Allah, Professor

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Prevalence of coronary heart disease risk factors and screening for high cholesterol levels among young adults, United States, 1999-2006.

Elena V Kuklina, Paula W Yoon, Nora L Keenan

https://pubmed.ncbi.nlm.nih.gov/20644187