Observational Study Using Perfusion Index to Guide Vasopressor Use in ICU Patients with Sepsis and Septic Shock

What this Trial Is About

Sepsis and septic shock are serious conditions with high mortality rates, often leading to low blood pressure due to damage to blood vessel lining. This research aims to explore the use of the perfusion index PI, a noninvasive measurement from pulse oximetry, to provide reliable information about blood flow in small vessels during sepsis. The study seeks to understand how PI can guide the timing of starting vasopressor medications, which are used to raise blood pressure in these patients. This observational study monitors patients in intensive care units who have suspected sepsis or septic shock. Vasopressor drugs will be started only if patients do not improve after receiving fluids. PI will be measured at the start of resuscitation, just before vasopressor therapy, and at various times over 24 hours to assess peripheral blood flow. The study will not assign treatments but will observe and record patient responses and treatments as they occur. Participants will be evaluated with multiple measurements including PI, blood pressure, heart rate, blood gas levels, and oxygen saturation at baseline, shortly after fluid resuscitation, and repeatedly over 24 hours. Additional scores assessing illness severity and mortality at 28 days will be recorded. This approach helps researchers understand how PI relates to patient condition and treatment needs, with the study expected to continue until March 2025.

Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis