Actively Recruiting
Observational Study Protocol: LIVER-R
Led by AstraZeneca · Updated on 2025-12-26
4490
Participants Needed
138
Research Sites
406 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
I
ICON plc
Collaborating Sponsor
AI-Summary
What this Trial Is About
Given the number of anticipated durvalumab-based treatment launches in the hepatobiliary cancer space over the next 3 years, there is a need to capture contemporary real-world data across these indications. LIVER-R is a multicountry, multicenter, observational study of patients with a confirmed diagnosis of hepatobiliary cancer treated with a durvalumab-based regimen as part of routine clinical practice or early access program (EAP). The study design will include primary and secondary data collection. The primary objective of this study is to evaluate the effectiveness of durvalumab-based regimens in real-world settings as measured by real-world overall survival. Other endpoints include demographics, clinical characteristics, clinically significant events of interest, treatment patterns, concomitant medications, and other real-world clinical endpoints (such as duration of treatment, progression-free survival, time to treatment progression, time to next treatment, recurrence-free survival, and time to treatment recurrence).
CONDITIONS
Official Title
Observational Study Protocol: LIVER-R
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and legally an adult in the country at the start of durvalumab treatment
- Confirmed diagnosis of primary hepatobiliary cancer (unresectable hepatocellular carcinoma or advanced biliary tract cancer) by the treating physician
- Hepatobiliary cancer type approved for durvalumab-based treatment in the country or treated as part of an early access program
- Informed consent obtained according to country regulations on or after the start of durvalumab treatment
You will not qualify if you...
- Currently participating, or planning to participate, in any clinical trial for investigational treatment for hepatobiliary cancers from diagnosis until starting durvalumab treatment
- Received other systemic therapies for hepatobiliary cancer from diagnosis until starting durvalumab treatment
- Received a liver transplant during the baseline period before starting durvalumab treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 138 locations
1
Research Site
Birmingham, Alabama, United States, 35233-1932
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2
Research Site
Mobile, Alabama, United States, 36604
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3
Research Site
Phoenix, Arizona, United States, 85004
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4
Research Site
Coronado, California, United States, 92118
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5
Research Site
Los Angeles, California, United States, 90048
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6
Research Site
Walnut Creek, California, United States, 94598
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7
Research Site
Clermont, Florida, United States, 34711
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8
Research Site
Gainesville, Florida, United States, 32610
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9
Research Site
Tampa, Florida, United States, 33606
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10
Research Site
Augusta, Georgia, United States, 30912
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11
Research Site
Evergreen Park, Illinois, United States, 60805
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12
Research Site
Hinsdale, Illinois, United States, 60521
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13
Research Site
Baton Rouge, Louisiana, United States, 70808
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14
Research Site
Osage Beach, Missouri, United States, 65065
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15
Research Site
White Plains, New York, United States, 10601
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16
Research Site
Canton, Ohio, United States, 44718
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17
Research Site
Bethlehem, Pennsylvania, United States, 18015
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18
Research Site
Philadelphia, Pennsylvania, United States, 19141
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19
Research Site
Dallas, Texas, United States, 75390-8567
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20
Research Site
Temple, Texas, United States, 76508
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21
Research Site
Spokane, Washington, United States, 99204
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22
Research Site
Garran, Australian Capital Territory, Australia, 2605
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23
Research Site
Heidelberg, Victoria, Australia, 3084
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24
Research Site
Melbourne, Victoria, Australia, 3004
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25
Research Site
Murdoch, Western Australia, Australia, 6150
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26
Research Site
Sankt Pölten, Lower Austria, Austria, 3100
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27
Research Site
Vienna, State of Vienna, Austria, 1090
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28
Research Site
Linz, Upper Austria, Austria, 4010
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29
Research Site
Brussels, Anderlecht, Belgium, 1070
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30
Research Site
Bonheiden, Antwerp, Belgium, 2820
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31
Research Site
Edegem, Antwerp, Belgium, 2650
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32
Research Site
Leuven, Brabant, Belgium, 3000
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33
Research Site
Liège, Wallonia, Belgium, 4000
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34
Research Site
Stene, West Flanders, Belgium, 8400
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35
Research Site
Curitiba, Paraná, Brazil, 81480-580
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36
Research Site
Recife - PE, Recife - PE, Brazil, 50070-490
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37
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
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38
Research Site
Morumbi, São Paulo, Brazil, 05651-901
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39
Research Site
São Paulo, Brazil, 01246-000
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40
Research Site
São Paulo, Brazil, 04538-132
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41
Research Site
Halifax, Nova Scotia, Canada, B3H 2Y9
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42
Research Site
Strasbourg, Alsace, France, 67000
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43
Research Site
Grenoble, Auvergne-Rhône-Alpes, France, 38700
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44
Research Site
St-Malo, Brittany Region, France, 35403
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45
Research Site
Mulhouse, Grand Est, France, 68100
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46
Research Site
Boulogne-sur-Mer, Hauts-de-France, France, 62200
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47
Research Site
Poitiers, New Aquitaine, France, 86000
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48
Research Site
Avignon, Provence-Alpes-Côte d'Azur Region, France, 84918
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49
Research Site
Marseille, Provence-Alpes-Côte d'Azur Region, France, 13008
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50
Research Site
Paris, Île-de-France Region, France, 75012
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51
Research Site
Paris, Île-de-France Region, France, 75014
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52
Research Site
Heidenheim, Baden W Rttemberg, Germany, 89522
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53
Research Site
Konstanz, Baden-Wurttemberg, Germany, 78484
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54
Research Site
Mannheim, Baden-Wurttemberg, Germany, 68167
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55
Research Site
Schorndorf, Baden-Wurttemberg, Germany, 73614
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56
Research Site
Stuttgart, Baden-Wurttemberg, Germany, 70174
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57
Research Site
Augsburg, Bavaria, Germany, 86150
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58
Research Site
Munich, Bavaria, Germany, 81377
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59
Research Site
Bremenhaven, Free Hanseatic City of Bremen, Germany, 27574
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60
Research Site
Kassel, Hesse, Germany, 34125
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61
Research Site
Marburg, Hesse, Germany, 35033
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62
Research Site
Wiesbaden, Hesse Land, Germany, 65189
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63
Research Site
Göttingen, Lower Saxony, Germany, 37075
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64
Research Site
Hanover, Lower Saxony, Germany, 30161
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65
Research Site
Hanover, Lower Saxony, Germany, 30459
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66
Research Site
Aachen, North Rhine-Westphalia, Germany, 52074
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67
Research Site
Bochum, North Rhine-Westphalia, Germany, 44892
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68
Research Site
Dortmund, North Rhine-Westphalia, Germany, 44137
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69
Research Site
Moers, North Rhine-Westphalia, Germany, 47441
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70
Research Site
Stolberg, North Rhine-Westphalia, Germany, 52222
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71
Research Site
Koblenz, Rhineland-Palatinate, Germany, 56073
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72
Research Site
Dresden, Saxony, Germany, 1307
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73
Research Site
Leipzig, Saxony, Germany, 4103
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74
Research Site
Halle, Saxony-Anhalt, Germany, 06108
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75
Research Site
Magdeburg, Saxony-Anhalt, Germany, 39120
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76
Research Site
Neumünster, Schleswig-Holstein, Germany, 24534
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77
Research Site
Berlin, Germany, 13353
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78
Research Site
Hamburg, Germany, 20259
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79
Research Site
Hamburg, Germany, 22291
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80
Research Site
Chaïdári, Athens, Greece, 12462
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81
Research Site
Athens, Attica, Greece, 11527
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82
Research Site
Athens, Attica, Greece, 14564
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83
Research Site
Thessaloniki, Central Macedonia, Greece, 54639
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84
Research Site
Thessaloniki, Central Macedonia, Greece, 55236
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85
Research Site
Larissa, Thessaly, Greece, 41110
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86
Research Site
Nahariya, Northern Didstrict, Israel, 22100
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87
Research Site
Ramat Gan, Tel Aviv, Israel, 52621
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88
Research Site
Jerusalem, Israel, 9103102
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89
Research Site
Tel Aviv, Israel, 6423906
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90
Research Site
Naples, Campania, Italy, 80131
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91
Research Site
Rome, Lazio, Italy, 00128
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92
Research Site
Rome, Lazio, Italy, 00168
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93
Research Site
Brescia, Lombardy, Italy, 25123
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94
Research Site
Milan, Lombardy, Italy, 20132
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95
Research Site
Milan, Lombardy, Italy, 20133
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96
Research Site
Rozzano, Lombardy, Italy, 20089
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97
Research Site
Turin, Piedmont, Italy, 10126
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98
Research Site
Monserrato, Sardinia, Italy, 09042
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99
Research Site
Pisa, Tuscany, Italy, 56124
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100
Research Site
Nagoya, Aichi-ken, Japan, 466-8550
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101
Research Site
Kashiwa-shi, Chiba, Japan, 277-8577
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102
Research Site
Kurume, Fukuoka, Japan, 830-0011
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103
Research Site
Kanazawa, Ishikawa-ken, Japan, 920-8641
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104
Research Site
Yokohama, Kanagawa, Japan, 241-8515
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105
Research Site
Kyoto, Kyoto, Japan, 606-8507
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106
Research Site
Sendai, Miyagi, Japan, 980-8574
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107
Research Site
Ōsaka-sayama, Osaka, Japan, 589-8511
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108
Research Site
Lisbon, Portugal, 1400 - 038
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109
Research Site
Lisbon, Portugal, 1649-028
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110
Research Site
San Juan, Rio Piedras, Puerto Rico, 00935
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111
Research Site
Bucharest, Romania, 22328
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112
Research Site
Cluj-Napoca, Romania, 400162
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113
Research Site
Iași, Romania, 700483
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114
Research Site
Riyadh, Ar Riyadh, Saudi Arabia, 12231
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115
Research Site
Jeddah, Mecca Region, Saudi Arabia, 22384
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116
Research Site
Singapore, Singapore, 329563
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117
Research Site
Santiago de Compostela, A Coruna, Spain, 15706
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118
Research Site
Zaragoza, Aragon, Spain, 50009
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119
Research Site
Santander, Cantabria, Spain, 39008
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120
Research Site
Burgos, Castille and León, Spain, 9006
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121
Research Site
Poniente Sur, Cordoba, Spain, 14004
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122
Research Site
Ourense, Galicia, Spain, 32005
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123
Research Site
El Palmar, Murcia, Spain, 30120
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124
Research Site
Barcelona, Spain, 8035
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125
Research Site
Madrid, Spain, 28007
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126
Research Site
Madrid, Spain, 28034
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127
Research Site
Madrid, Spain, 28040
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128
Research Site
Oviedo, Spain, 33011
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129
Research Site
Pamplona, Spain, 31008
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130
Research Site
Santa Cruz de Tenerife, Spain, 38010
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131
Research Site
Seville, Spain, 41009
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132
Research Site
Valencia, Spain, 46010
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133
Research Site
Zurich, Switzerland, 8032
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134
Research Site
Kaohsiung City, Taiwan, 82445
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135
Research Site
Taipei, Taiwan, 100225
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136
Research Site
Taipei, Taiwan, 11217
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137
Research Site
Taoyuan City, Taiwan, 33305
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138
Research Site
Mohammed Bin Zayed City, Abu Dhabi Emirate, United Arab Emirates, 92510
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Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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