Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography

What this Trial Is About

Researchers are conducting an observational study to use optical coherence tomography (OCT) technology to measure corneal swelling, also called corneal edema, in people with Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy. The study aims to predict changes in vision that may occur as the swelling resolves after surgical treatments. This study is sponsored by Oregon Health and Science University and focuses on understanding corneal changes over time in these eye conditions. The study includes two groups: one group of adults 18 years or older with these conditions who do not need surgery according to standard care, and another group of adults who do require surgery such as Descemet's Stripping Endothelial Keratoplasty (DSAEK), Descemet's Membrane Endothelial Keratoplasty (DMEK), or Descemet's Stripping Only (DSO). The surgery decisions are made by the attending physician following usual care guidelines. The study does not assign or pay for treatments. Participants will be followed for up to two years, during which OCT imaging will be used to evaluate the corneal epithelial and stromal edema or haze. Researchers will monitor changes in the cornea and vision after treatment or during observation. Participants must commit to attending required study visits. The study does not involve additional treatments but focuses on imaging and clinical assessments to better understand corneal health and vision changes in these eye conditions.

OCT in Fuchs' Dystrophy