Study of OCT Vibrography to Measure Biomechanical Properties in Healthy Tissues and Keratoconus Eyes

What this Trial Is About

Researchers are evaluating OCT Vibrography, also known as OCT elastography, as a new technique to measure the biomechanical properties of human tissues like the cornea, skin, and gingiva. The study aims to establish baseline data in healthy individuals, compare tissue elasticity, and investigate differences between normal eyes and those affected by keratoconus. This research could improve understanding of tissue structure and support better diagnosis and treatment of keratoconus and inflammatory skin and gingival diseases. Participants will undergo optical imaging of their cornea, skin, or gingiva using the OCT Vibrography device. The study includes healthy volunteers as well as participants with mild to moderate keratoconus. Different groups will have their tissues imaged to collect data on elastic properties. The study is randomized and involves no masking or blinding. During the study, researchers will monitor participants for any serious unexpected problems related to the device use over one year. Participants will receive assessments involving optical imaging, and their data will help measure tissue elasticity. The total participation duration varies by individual, with safety and feasibility as key outcomes. The study is sponsored by Massachusetts General Hospital and is open to adults aged 18 to 75 years.

OCT Vibrography for Biomechanical Properties of Tissues