Actively Recruiting
Acute Effects of Cigarette Smoking on Corneal Tomographic and Biometric Parameters: A Prospective Controlled Study
Led by Istanbul University · Updated on 2026-05-12
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the immediate effects of cigarette smoking on the cornea's structure and measurements in healthy adults aged 18 to 60 years. This prospective, controlled study compares smokers and non-smokers to see if short-term smoking causes measurable changes in corneal tomography and biometric parameters. The study includes 46 smokers and 46 non-smokers to better understand how acute smoking exposure might affect eye health. Participants are divided into two groups: active smokers and non-smokers. Both groups undergo initial full eye examinations and measurements using a Pentacam device focused on the right eye to avoid data overlap. After baseline measurements, participants spend 10 minutes outdoors under standard conditions; smokers smoke during this period while non-smokers do not. The same eye measurements are taken immediately after this exposure period to compare changes within and between the groups. Throughout the study, participants undergo detailed eye exams and Pentacam imaging to measure corneal thickness and densitometry at the pupil center before and after the smoking or non-smoking exposure. Researchers monitor changes in these parameters to assess the acute impact of smoking on eye structures. The study duration includes baseline assessment, the 10-minute exposure period, and immediate post-exposure measurements to capture short-term effects.
CONDITIONS
Brief Title
Acute Ocular Effects of Cigarette Smoking
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 18 to 60 years
- Current smokers in the smoking group
- Never-smokers in the control group
- Willing and able to undergo ophthalmic examination and Pentacam AXL measurements
You will not qualify if you...
- History of ocular surgery or ocular trauma
- Presence of corneal disease, retinal disease, or ocular surface disorder
- Clinically significant dry eye disease
- Contact lens use within the last 2 weeks
- Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics
- Systemic diseases such as diabetes mellitus or hypertension
- Former smoking history in the control group
- Use of electronic cigarettes or other tobacco products
- Inability to cooperate adequately for accurate measurement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline ophthalmic examination and Pentacam measurements to assess corneal parameters.
1 visit (in-person)
Duration - 10 minutes
Participants wait in a standardized outdoor environment for 10 minutes during which smokers smoke and non-smokers do not, followed by repeat ophthalmic measurements.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Istanbul University, Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye), 34093
Actively Recruiting
Research Team
S
Semih Çakmak
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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