Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT07536204

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

Led by University of Chile · Updated on 2026-04-17

30

Participants Needed

1

Research Sites

199 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.

CONDITIONS

Official Title

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults
  • Sistemically healthy
Not Eligible

You will not qualify if you...

  • Active Maliganancy
  • History of radiation to the head-neck region
  • Chemotherapy or radiation within the last 5 years
  • History of hepatitis B/C or HIV infection
  • Autoimmune diseases
  • Diagnosis of diabetes
  • Pregnancy or lactation
  • More than 3 hospitalizations over the last 3 years
  • Use of systemic antibiotics over the last 3 months
  • Use of systemic corticosteroids or immunosuppressants over the last 3 months
  • Use of cytokine therapy over the last 3 months
  • Use of large doses of pre/probiotic supplements over the last 3 months
  • Smoke more than 10 cigarettes per day

AI-Screening

AI-Powered Screening

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2
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Trial Site Locations

Total: 1 location

1

Faculty of Dentistry, University of Chile

Santiago, Metropolitan Region, Chile

Actively Recruiting

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Research Team

N

Nicolas Dutzan, DDS, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis | DecenTrialz