Actively Recruiting
Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
Led by University of Chile · Updated on 2026-04-17
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining the activation of the JAK1 and JAK2 pathways in gum tissues to understand their role in gum health and inflammation, specifically periodontitis. This observational study compares these pathways in adults with healthy gums and those with inflamed gums due to periodontitis. The study also aims to describe which tissue areas and cell types show activation of these pathways. Participants include adults with either healthy gums or periodontitis, identified by clinical exams. Each participant will have a gingival tissue biopsy taken during a single study visit. There are no drug treatments or interventions; the study focuses on collecting and analyzing tissue to understand the immune pathways involved in gum disease. During the study, participants will donate gum tissue for analysis and receive diagnosis and treatment for their gum condition. Researchers will measure JAK1/2 pathway activation in the tissue samples collected on the day of biopsy. Participation involves one visit for tissue donation, with no further follow-up visits required. The study seeks to improve understanding of periodontitis and potential therapeutic targets.
CONDITIONS
Brief Title
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults
- Sistemically healthy
You will not qualify if you...
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
- Diagnosis of diabetes
- Pregnancy or lactation
- More than 3 hospitalizations over the last 3 years
- Use of systemic antibiotics over the last 3 months
- Use of systemic corticosteroids or immunosuppressants over the last 3 months
- Use of cytokine therapy over the last 3 months
- Use of large doses of pre/probiotic supplements over the last 3 months
- Smoke more than 10 cigarettes per day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo gingival tissue biopsy to examine JAK1/2 pathway activation in healthy and inflamed gingiva.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, University of Chile
Santiago, Metropolitan Region, Chile
Actively Recruiting
Research Team
N
Nicolas Dutzan, DDS, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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