Study of JAK1 and JAK2 Pathway Activation in Healthy and Inflamed Gingiva Exploring Immune Pathways in Periodontitis and Potential Treatments

What this Trial Is About

Researchers are examining the activation of the JAK1 and JAK2 pathways in gum tissues to understand their role in gum health and inflammation, specifically periodontitis. This observational study compares these pathways in adults with healthy gums and those with inflamed gums due to periodontitis. The study also aims to describe which tissue areas and cell types show activation of these pathways. Participants include adults with either healthy gums or periodontitis, identified by clinical exams. Each participant will have a gingival tissue biopsy taken during a single study visit. There are no drug treatments or interventions the study focuses on collecting and analyzing tissue to understand the immune pathways involved in gum disease. During the study, participants will donate gum tissue for analysis and receive diagnosis and treatment for their gum condition. Researchers will measure JAK12 pathway activation in the tissue samples collected on the day of biopsy. Participation involves one visit for tissue donation, with no further follow-up visits required. The study seeks to improve understanding of periodontitis and potential therapeutic targets.

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis