Actively Recruiting
Optimization of Patient Preparation and Imaging Techniques for Cardiac CT
Led by Karolinska University Hospital · Updated on 2025-03-17
240
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to find the best way to lower heart rate before a special type of heart imaging called Computed Tomography of the coronary vessels (CCTA). The study compares four different methods to reduce heart rate, which is important because a high heart rate can make imaging harder and may increase radiation exposure. The study also looks at whether listening to music during the procedure helps improve patient comfort and experience. Participants are randomly assigned to one of four groups. One group receives oral beta-blocker medication (Seloken), another gets intravenous Metoprolol directly at the CT table, a third group rests for one hour before receiving intravenous Metoprolol, and the last group receives oral Seloken plus intravenous Metoprolol along with calming music before and during the CT scan. The doses and timing vary, including a waiting period where applicable. During the study, heart rate is monitored from enrollment until the end of the examination, which lasts about 1.5 hours. Participants also report their feelings of anxiety and comfort using visual scales. Researchers measure heart rate stability, reduction, and participant-reported experiences to determine which preparation method works best. The study includes 240 adults and involves standard clinical assessments and heart rate monitoring throughout the procedure.
CONDITIONS
Brief Title
Optimization of Patient Preparation and Imaging Techniques for Cardiac CT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant with a preexisting referral for a Cardiac CT examination
- Age 18 years or older
You will not qualify if you...
- Age under 18 years
- Atrial fibrillation
- Pacemaker
- Participation in clinical drug trials
- Contraindications to beta-blockers
- Severe medical conditions
- Challenges in comprehending study information
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants are screened before enrollment.
Duration - Approximately 1.5 hours from enrollment to end of examination
Participants receive beta-blocker interventions and cardiac CT scans according to their assigned group. This includes oral and/or intravenous Metoprolol administration, with some groups resting for 1 hour before intravenous dosing, and one group also listening to calming music before and during the scan.
1 visit (in-person) including preparation and cardiac CT imaging
Trial Site Locations
Total: 1 location
1
ME Radiologi Huddinge, Karolinska University Hospital
Stockholm, Huddinge, Sweden, 141 86
Actively Recruiting
Research Team
A
Aziza Adem Adem, MSc
A
Anders Svensson-Marcial, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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