Actively Recruiting

Phase Not Applicable
Age: 50Years +
All Genders
ID05293756

OPtimizing Technology to Improve Medication Adherence and Blood Pressure Control

Led by Case Western Reserve University · Updated on 2026-04-03

208

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

C

Case Western Reserve University

Lead Sponsor

U

University Hospitals Cleveland Medical Center

Collaborating Sponsor

AI-Summary

What this Trial Is About

Hypertension (HTN) significantly impacts African American (AA) older adults more than any other U.S. racial group, contributing to higher rates of disability, death, and healthcare use. This trial evaluates a technology-based approach called OPTIMA-BP to support self-management of HTN and improve blood pressure control over 12 months. It focuses on AA adults aged 50 and older, aiming to reduce health disparities and improve quality of life by targeting medication adherence and lifestyle behaviors. Participants are randomly assigned to either receive the OPTIMA-BP intervention immediately for 6 months followed by a 6-month observation period, or to a 6-month waitlist control before receiving the intervention for 6 months. The OPTIMA-BP intervention includes six weekly web-based education sessions about hypertension management, access to the Medisafe medication management app with reminders and feedback, home blood pressure monitoring twice daily twice a week, nurse counseling sessions for support, and coordination with their physician to optimize hypertension treatment. During the study, participants monitor their blood pressure at home and keep tracking logs. They also complete assessments of blood pressure control and health-related quality of life at baseline and 6 months. Researchers will collect biological risk markers and measure blood pressure control below 130/80 mmHg. The trial involves regular follow-up, support, and data collection over the 12-month period to evaluate the effectiveness of the intervention in improving self-management and health outcomes.

CONDITIONS

Brief Title

OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

Who Can Participate

Age: 50Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Self-identify as African American
  • 50 years of age or older
  • Diagnosed with hypertension with systolic blood pressure between 130 mmHg and less than 170 mmHg
  • Prescribed at least two antihypertensive medications, including a diuretic/thiazide or calcium channel blocker
  • Own a smartphone with a data plan and can download the Medisafe app or view videos
  • Able to read and understand English
Not Eligible

You will not qualify if you...

  • Unable to give informed consent or have impaired cognitive ability or severe memory problems
  • Currently using a medication management application
  • Experienced a major cardiovascular event or procedure such as heart attack, stroke, or heart surgery within the past year
  • Diagnosed with chronic kidney disease with eGFR less than 60 ml/min/1.73m2 or receiving dialysis

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 6 months

Participants receive the OPTIMA-BP intervention, including six weekly web-based education sessions on hypertension management, access to the Medisafe medication management app, home blood pressure monitoring twice weekly, and nurse counseling sessions for support and follow-up.

Weekly web-based sessions and regular nurse counseling sessions over 6 months

Follow-up

Duration - 6 months

Participants are observed for an additional 6 months after completing the OPTIMA-BP intervention to monitor blood pressure control and health-related quality of life.

Periodic assessments during follow-up

Trial Site Locations

Total: 1 location

1

Case Western Reserve University

Cleveland, Ohio, United States, 44143

Actively Recruiting

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Research Team

C

Carolyn Still, PHD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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