Actively Recruiting
Ovarian Platelet-Rich Plasma (oPRP) Injections to Improve IVF Outcomes Using Time-Lapse Imaging and AI Embryo Quality Assessment
Led by Generation Next Fertility · Updated on 2025-07-09
180
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of ovarian platelet-rich plasma (oPRP) injections to improve embryo quality in patients undergoing in vitro fertilization (IVF). This study focuses on patients with infertility, poor ovarian reserve, or embryo growth disorders and uses advanced time-lapse imaging and artificial intelligence (AI) software to track and assess embryo development. The trial is a non-randomized prospective self-controlled interventional study sponsored by Generation Next Fertility. Participants will undergo two IVF cycles. The first cycle occurs before receiving ovarian PRP treatment. Afterward, patients receive their first oPRP injection under IV sedation, where their own PRP is injected into both ovaries guided by transvaginal ultrasound. In the second IVF cycle, the same ovarian stimulation protocol is followed, with a second oPRP injection early in stimulation to enhance follicle growth. Egg retrieval and fertilization follow the same protocols as the first cycle, with embryos cultured in an AI-equipped incubator for detailed monitoring. During the study, up to 15 embryos per patient will be observed using time-lapse imaging and AI analysis to evaluate their growth and quality. Researchers will measure blastocyst formation and embryo quality over one year, with live birth rates tracked over two years. The study involves close monitoring of ovarian response, embryo development, and pregnancy outcomes, providing detailed data on the effects of oPRP treatment in IVF patients.
CONDITIONS
Brief Title
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 to 47 years
- No contraindications to IVF or PRP treatment
- Adequate ovarian reserves and AMH level
- Willingness to undergo two IVF cycles and ovarian PRP treatment
You will not qualify if you...
- Anovulation due to menopause or perimenopause
- Any health conditions contraindicating IVF or ovarian PRP treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 to 2 weeks after the onset of the next menstrual cycle
Participants receive autologous platelet-rich plasma (PRP) injections into both ovaries to potentially improve embryo quality.
1 injection visit under IV sedation and transvaginal ultrasound guidance
Duration - Typical IVF cycle duration
Participants undergo their first IVF cycle to assess baseline embryo development using time-lapse imaging and AI analysis.
Multiple visits for ovarian stimulation, ovulation trigger, and oocyte retrieval
Duration - Second IVF cycle duration with stimulation days 2-5 including second PRP injection
Participants undergo a second IVF cycle including a second ovarian PRP injection during stimulation to evaluate changes in embryo quality.
1 PRP injection visit during stimulation and multiple IVF procedure visits
Trial Site Locations
Total: 1 location
1
Generation Next Fertility
New York, New York, United States, 10022
Actively Recruiting
Research Team
A
Alicia L Broussard, PhD
J
Jesse Hade, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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