Ovarian Platelet-Rich Plasma Injections to Improve Embryo Quality in IVF Patients Using AI and Time-Lapse Imaging A Self-Controlled Treatment Study

What this Trial Is About

Researchers are evaluating the use of ovarian platelet-rich plasma oPRP injections to improve embryo quality in patients undergoing in vitro fertilization IVF. This study focuses on patients with infertility, poor ovarian reserve, or embryo growth disorders and uses advanced time-lapse imaging and artificial intelligence AI software to track and assess embryo development. The trial is a non-randomized prospective self-controlled interventional study sponsored by Generation Next Fertility. Participants will undergo two IVF cycles. The first cycle occurs before receiving ovarian PRP treatment. Afterward, patients receive their first oPRP injection under IV sedation, where their own PRP is injected into both ovaries guided by transvaginal ultrasound. In the second IVF cycle, the same ovarian stimulation protocol is followed, with a second oPRP injection early in stimulation to enhance follicle growth. Egg retrieval and fertilization follow the same protocols as the first cycle, with embryos cultured in an AI-equipped incubator for detailed monitoring. During the study, up to 15 embryos per patient will be observed using time-lapse imaging and AI analysis to evaluate their growth and quality. Researchers will measure blastocyst formation and embryo quality over one year, with live birth rates tracked over two years. The study involves close monitoring of ovarian response, embryo development, and pregnancy outcomes, providing detailed data on the effects of oPRP treatment in IVF patients.

Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score