Evaluating Adenoma Detection Rates Across Different Colonoscopy Indications in Adults Aged 50 to 80

What this Trial Is About

Researchers are evaluating whether the overall adenoma detection rate ADR can be a reliable alternative to the screening ADR in colonoscopy procedures. This prospective multicenter study involves 18 colonoscopists from five hospitals in Taiwan and plans to recruit 2,700 participants aged 50 to 80 years over two years. The study includes patients undergoing colonoscopy for screening, surveillance, diagnostic reasons, or positive fecal immunochemical test FIT results. The goal is to compare ADRs across these groups and explore correlations between screening ADR and overall ADR including or excluding FIT-positive cases. Participants will be grouped based on their colonoscopy indication screening asymptomatic with no or negative prior colonoscopy, surveillance with prior colon neoplasms, diagnostic symptomatic or abnormal test findings, and FIT-positive positive FIT results regardless of recent colonoscopy. The study will compare ADRs using traditional screening definitions and combined indications, including the impact of adding FIT-positive patients to overall ADR calculations. During the study, participants will undergo colonoscopy according to their indication. Researchers will measure the adenoma detection rate within 7 days as the primary outcome. Data collection will include categorizing patients and analyzing ADR correlations. The study will monitor participants throughout the procedure and follow-up as needed, with a total study duration of two years and study completion planned by September 2026.

Can Overall Adenoma Detection Rate Replace Screening Adenoma Detection Rate ? Multicenter Study