Actively Recruiting
Paravertebral Muscles Assessment Using High-resolution MRI in Children Suffering From Idiopathic or Neuromuscular Scoliosis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-08-22
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring differences in the muscles alongside the spine in children with scoliosis, a condition where the spine curves abnormally. This study focuses on comparing children with two types of scoliosis: idiopathic, which has no known cause, and neuromuscular, which relates to muscle or nerve problems. The aim is to understand if muscle issues play a role in the development or progression of idiopathic scoliosis by using detailed imaging techniques. Participants will undergo a standard axial MRI scan to examine their spinal cord, with an additional 5-minute sequence called Diffusion Tensor Imaging (DTI) to study the paravertebral muscles in high detail. The study will compare muscle characteristics such as area, fiber number, and other MRI values between the curved sides of the spine and between the two scoliosis groups. Children aged 10 to 17 years with scoliosis that meets specific criteria will be included. During the study visit, children will complete a questionnaire about their physical activity and sedentary habits. The MRI images will be analyzed with specialized software to measure muscle features in defined spinal regions. The research team will look for differences in muscle morphology related to scoliosis type and curve side. This observational period involves data collection and analysis, with statistical methods used to compare findings, aiming to improve understanding of scoliosis muscle involvement.
CONDITIONS
Brief Title
Paravertebral Muscles Assessment Using High-resolution MRI in Idiopathic or Neuromuscular Scoliosis Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children and adolescents aged 10 to 17 years old
- Diagnosed with idiopathic or neuromuscular scoliosis that is not collapsing
- Cobb angle less than 40 degrees
- Female participants preferred
- Able to walk
- Average or low body mass index below 20 kg/m2
- Signed informed consent from legal guardians
- Affiliated with a social security scheme (beneficiary or dependent)
You will not qualify if you...
- Refusal by the patient or parents to participate
- Inability to cooperate with study procedures
- Contraindication to MRI
- History of spinal surgery
- Not affiliated with a social security scheme (beneficiary or entitled person)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (routine consultation)
Duration - Single day
Participants who are eligible and consent to participate undergo an MRI scan with an additional 5-minute lying down position for a specific muscle imaging sequence. They also complete the CAPAS-Q questionnaire on physical activity and sedentary behaviour during this visit.
1 visit (in-person MRI and questionnaire)
Duration - Ongoing after imaging
Imaging data collected during the MRI are pseudonymised and analyzed to assess morphological differences in paravertebral muscles between scoliosis types and regions.
No additional visits required
Trial Site Locations
Total: 1 location
1
CHU Raymond Poincaré - APHP
Garches, France, 92380
Actively Recruiting
Research Team
H
Hélène Gouz, MD
M
Marie-Line PISSONNIER, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here