Personalized Prevention Program Based on Comprehensive Geriatric Assessment to Reduce Frailty and Hospitalization in Older Adults with Chronic Diseases in Primary Care

What this Trial Is About

Researchers are evaluating the effectiveness of a personalized prevention program PPP based on the Comprehensive Geriatric Assessment CGA for older adults with non-communicable chronic diseases NCDs. The study aims to reduce hospitalization rates and explore biological factors related to aging and frailty. This research involves 1216 participants recruited by General Practitioners GPs in Italy and focuses on the impact of the CGA in primary care settings. Participants are randomly assigned to two groups an intervention group that receives the PPP guided by the CGA and a control group receiving standard clinical care. The PPP includes assessments using the Brief-MPI scale covering motor, cognitive, nutritional, medication, vaccination, daily activities, and living situation domains. Participants in the intervention group receive brochures with tailored advice for 12 months, specialist referrals if needed, and provide saliva samples for biomarker analysis. The control group continues usual care without CGA evaluation or saliva collection. All participants will be monitored at baseline, 6 months, and 12 months with follow-up contacts to assess adherence, satisfaction, and health outcomes. Researchers will measure hospitalization rates as the primary outcome and secondary outcomes including combined health events, unplanned GP visits, and mortality rates. The study also collects data on psychological wellbeing and resilience. Statistical analyses will compare outcomes between groups over 12 months to assess the programs impact.

A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People