Actively Recruiting
Dietary Pistachio Intake and Nutrition-Related Outcomes in Individuals Using GLP-1 Receptor Agonists: A Randomized Controlled Trial
Led by Ian J. Neeland, MD · Updated on 2026-02-20
108
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how eating pistachios daily may affect weight, diet quality, and feelings related to eating in adults who have been using GLP-1 medicines like semaglutide or tirzepatide for at least three months. The study aims to find out if adding pistachios to meals for 12 weeks can help participants feel fuller, increase energy, and improve body composition and health markers such as tiredness and blood levels. Participants will be randomly assigned to one of two groups: one group will eat 2 ounces (about 53 grams) of dry-roasted, unsalted pistachios daily alongside their regular diet, while the other group will continue their usual diet without pistachios. The study lasts 12 weeks and includes monitoring changes in diet, energy, mood, and various health indicators. During the trial, participants will have their satiety, fatigue, mood, dietary quality, food enjoyment, blood sugar, cholesterol levels, and physical activity measured at the start and end of the study. Body weight, waist and hip measurements, and body composition will also be assessed using medical records and DEXA scans. This comprehensive evaluation will help researchers understand the effects of pistachio intake while on GLP-1 therapy over the 12-week period.
CONDITIONS
Brief Title
Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Body mass index (BMI) of 30 kg/m2 or higher, or BMI of 27 kg/m2 or higher with at least one weight-related health condition
- Currently using semaglutide or tirzepatide continuously for at least three months for a clinical reason and still on treatment at enrollment
You will not qualify if you...
- Not using or unable to use GLP-1 receptor agonists
- Known allergy to nuts
- Pregnant or breastfeeding
- Currently incarcerated
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants follow their assigned diet for 12 weeks, either eating 2 ounces of dry-roasted, unsalted pistachios daily along with their regular diet or continuing their regular diet without pistachios.
Baseline visit and 1 follow-up visit at the end of study
Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center
Clevland, Ohio, United States, 44106
Actively Recruiting
Research Team
I
Ian Neeland, MD
A
Abigail Raffner, PhD, RD, LD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here