Actively Recruiting
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
Led by Maastricht University Medical Center · Updated on 2024-12-05
226
Participants Needed
1
Research Sites
630 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life. Moreover, it is known that often the pregnancy induced CV adaptation does not resolve completely after a short postpartum (PP) period and it is not clear whether these induced changes will resolve over a longer period of time (i.e. in the upcoming months/years after delivery). Understanding the cardiac adaptation during pregnancy and the reversal process in the postpartum period, as well as the factors that influence this these processes, may provide us not only insight in this mechanism, but may help us in identifying factors that may be target points for modification.
CONDITIONS
Official Title
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older
- Controls: Women with an uncomplicated pregnancy at inclusion (no placental complications such as pregnancy-induced hypertension, preeclampsia, HELLP syndrome, or small for gestational age birth)
- Cases: Women diagnosed with preeclamptic pregnancy at inclusion
You will not qualify if you...
- Women unwilling to be informed about test results or have their doctors informed
- Allergy or intolerance to glyceryl trinitrate, beta-blockers, or iodinated contrast media
- Controls with pre-existing chronic hypertension treated with medication or autoimmune disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Maastricht University Medical Center (MUMC+)
Maastricht, Netherlands, 6202 AZ
Actively Recruiting
Research Team
G
Gwyneth Jansen, MBBS
CONTACT
M
Marc Spaanderman, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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