Actively Recruiting
Advanced Fetal Imaging - Phase II to Improve MRI for Pregnant Women and Their Fetuses
Led by Boston Children's Hospital · Updated on 2025-12-08
300
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
M
Massachusetts Institute of Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are working to improve fetal MRI imaging by designing special MRI coils for pregnant women and testing new image capture techniques. The goal is to get clearer and more reliable fetal MRI images compared to current clinical methods. This project focuses on both structural and physiological imaging of fetuses by developing new MRI pulse sequences and faster imaging coils. Pregnant women who can have an MRI may join either a 60-minute full research MRI scan or a 15-minute add-on research MRI scan. The full scan tests an investigational MRI coil made for pregnant women alongside new MRI sequences to enhance image quality and speed. The add-on scan is for women who already have a clinical fetal MRI scheduled at Boston Children's Hospital and will test the new MRI sequences. Participants will undergo MRI scans lasting either 15 or 60 minutes depending on their group. Researchers will compare the quality of the research MRI images to standard clinical fetal MRI and obstetric ultrasound images. They will also compare physiological data from the research MRI to ultrasound data. The study includes safety monitoring and aims to complete data collection by mid-2028.
CONDITIONS
Brief Title
Advanced Fetal Imaging - Phase II
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women aged 18 to 45 years
- Gestational age between 18 and 40 weeks
- Pregnant women with a healthy pregnancy
- Pregnant women with concerns for fetal or placental abnormalities referred for clinical fetal MRI
- Pregnant women with concerns for fetal or placental abnormalities not referred for clinical fetal MRI
- For the 15-minute add-on scan, clinical fetal MRI must be scheduled at Boston Children's Hospital
You will not qualify if you...
- Pregnant women with contraindications to MRI (such as implanted metal, non-removable piercings, pacemaker)
- Pregnant women who are claustrophobic
- Pregnant women medically unstable for MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single imaging session
Participants undergo fetal MRI scans using investigational MRI coils and new imaging technologies to improve fetal image quality and speed.
1 visit (in-person) lasting 15 to 60 minutes depending on the assigned scan type
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
P
P. Ellen Grant, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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