Study of Mitochondrial Dysfunction in Women Aged 20 to 45 With Polycystic Ovary Syndrome, Insulin Resistance, Infertility, and Obesity

What this Trial Is About

This research aims to understand the role of mitochondrial dysfunction in women diagnosed with polycystic ovary syndrome PCOS, insulin resistance, infertility, and related conditions. PCOS is a complex disorder affecting women of reproductive age, characterized by endocrine problems such as ovulatory dysfunction, obesity, insulin resistance, and specific ovarian changes. The study explores how mitochondrial issues may contribute to these conditions and their impact on fertility and metabolism. The study plans to enroll 150 female patients of fertile age with PCOS, insulin resistance, infertility, or mitochondrial disease, along with the same number of age- and sex-matched healthy controls. Researchers will examine biomarkers linked to mitochondrial dysfunction, including mitochondrial DNA abnormalities. The focus is on mitochondrial dynamics, bioenergetics, and autophagy pathways to better understand their role in PCOS and insulin resistance. Participants will be observed over one year, with researchers measuring serum glucose and insulin levels as primary outcomes, along with clinical pregnancy rates. Secondary outcomes include hormone level assessments such as female sex hormones and thyroid hormones. The study involves collecting clinical data and biomarker information to improve understanding and potentially identify new biomarkers or treatment targets. The total duration and participation involve regular assessments over the study period.

Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort