Study on Muscle Strength and Physical Activity in Adults with Polyneuropathy Compared to Healthy Adults

What this Trial Is About

Researchers are investigating the accuracy and consistency of tests that measure muscle strength, movement abilities like walking and balance, daily physical activity, and patient-reported function in people with polyneuropathy. The study also compares these factors between patients with different types of polyneuropathy and healthy adults. Various subtypes of polyneuropathy being studied include chronic inflammatory demyelinating polyneuropathy, vasculitis polyneuropathy, POEMS syndrome, multifocal motor neuropathy, Charcot-Marie-Tooth disease, hATTR amyloidosis, diabetic polyneuropathy, and idiopathic neuropathy. The study involves four phases where clinical tests, patient questionnaires, and physical activity tracking with accelerometers are used to evaluate participants. About 400 adults diagnosed with polyneuropathy and 120 healthy adults will participate. Patients will be tested and complete outcome measures at the start, again after 2 to 4 weeks, and once more after 1 to 2 years. Healthy controls will be tested once at the baseline visit without follow-up. Participants in the patient group will undergo various walking, strength, and motor skill tests multiple times over the study period. They will also wear motion sensors to monitor physical activity and fill out questionnaires about symptoms, daily functioning, fatigue, sleep quality, and mood. The main outcomes include several walking and strength tests measured at baseline, after several weeks, and after up to two years. Safety and long-term effects will be monitored throughout the study duration, which lasts up to two years for patients.

Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study