Actively Recruiting
Application of Positive Psychology Interventions in Individuals With Early-stage Cognitive Decline Related to Dementia: Their Impact on Cognitive and Brain Functioning
Led by Aristotle University Of Thessaloniki · Updated on 2026-01-07
128
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
A
Aristotle University Of Thessaloniki
Lead Sponsor
A
Alzheimer Hellas
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults experiencing the earliest stages of dementia-related decline. This randomized study involves about 128 participants diagnosed with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI). The study aims to compare the effects of the Positive Psychology program with Treatment As Usual (TAU) on cognitive performance and brain function. The Positive Psychology program includes weekly online small-group sessions lasting about 60 minutes for approximately 16 weeks, along with brief daily home practices of about 10 minutes. It focuses on identifying and using character strengths and mindfulness, guided by trained psychologists. Participants in the TAU group continue their usual cognitive training without additional positive psychology content. Both groups complete assessments at baseline, mid-intervention, post-intervention, and nine-month follow-up. During the study, participants will undergo questionnaires and cognitive tests, including computerized batteries measuring memory, attention, and executive function, as well as brain function assessments using EEG and functional near-infrared spectroscopy (fNIRS). Attendance and home practice adherence are monitored, and adverse events are tracked. The main outcomes will assess cognitive improvement and brain connectivity after treatment and at nine months. Secondary outcomes include wellbeing, mindfulness, and character strengths. The study lasts approximately nine months beyond treatment to evaluate lasting effects.
CONDITIONS
Brief Title
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented diagnosis of Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI) according to clinical evaluation and site standard criteria.
You will not qualify if you...
- Diagnosis of dementia or other major neurocognitive disorder that is moderate or severe.
- Major psychiatric disorder currently unstable or untreated (e.g., major depression with psychotic features, bipolar disorder, schizophrenia).
- Neurological conditions that affect cognition.
- Uncorrected hearing or vision problems that prevent participation in assessments or online sessions.
- Concurrent participation in another interventional study targeting cognition or wellbeing during the study period.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for eligibility assessment
Duration - Approximately 16 weeks
Participants engage in weekly online group sessions of the Positive Psychology Intervention led by trained psychologists, or continue their usual cognitive training program.
Weekly sessions (about 1 hour each) plus brief daily home practice (about 10 minutes) for those in the Positive Psychology Intervention arm
Duration - Approximately 9 months
Participants complete assessments to evaluate the lasting effects of the intervention approximately 9 months after the treatment ends.
1 visit (remote or in-person) for follow-up assessment
Trial Site Locations
Total: 1 location
1
Aristotle University of Thessaloniki
Thessaloniki, Greece, 54124
Actively Recruiting
Research Team
D
Dimitra Vasileiou, M.Sc., PhD candidate
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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