Actively Recruiting
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
Led by Aristotle University Of Thessaloniki · Updated on 2026-01-07
128
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
Sponsors
A
Aristotle University Of Thessaloniki
Lead Sponsor
A
Alzheimer Hellas
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline. About 128 participants with Subjective Cognitive Decline or Mild Cognitive Impairment will be enrolled. Half will be randomized to the Positive Psychology program and half to Treatment As Usual (TAU). The program consists of weekly, small-group online sessions for \~24 weeks plus brief home practices. All participants (both arms) will complete questionnaires and cognitive tests at baseline, during treatment, post-treatment, and 9-month follow-up. Primary question: Do participants receiving the Positive Psychology program show better cognitive and brain-function outcomes than TAU at post-treatment and at 9 months? Secondary question: Are effects larger for SCD than MCI? No medicines are used and risks are minimal. If effective, this scalable, low-cost, non-pharmacological approach could complement usual care for people in very early cognitive decline.
CONDITIONS
Official Title
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented diagnosis of Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI) according to clinical evaluation and site standard criteria.
You will not qualify if you...
- Diagnosis of dementia (major neurocognitive disorder) or other major neurocognitive disorder that is moderate or severe.
- Major psychiatric disorder currently unstable or untreated (e.g., major depression with psychotic features, bipolar disorder, schizophrenia).
- Neurological conditions that affect cognition.
- Uncorrected hearing or vision problems that prevent participation in assessments or online sessions.
- Concurrent participation in another interventional study targeting cognition or wellbeing during the study period.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Aristotle University of Thessaloniki
Thessaloniki, Greece, 54124
Actively Recruiting
Research Team
D
Dimitra Vasileiou, M.Sc., PhD candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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