Actively Recruiting
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Led by Istituto per la Ricerca e l'Innovazione Biomedica · Updated on 2026-06-08
200
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
Sponsors
I
Istituto per la Ricerca e l'Innovazione Biomedica
Lead Sponsor
A
Azienda Ospedaliera Universitaria Renato Dulbecco
Collaborating Sponsor
AI-Summary
What this Trial Is About
Mild Cognitive Impairment (MCI) is a condition linked to an increased risk of developing dementia. While cognitive changes have been the main focus, this research is exploring how motor changes may also appear early in cognitive decline and could serve as early signs of disease. The study aims to better understand motor reserve, which is how motor abilities might help compensate for cognitive decline, by examining both healthy people and those with MCI through detailed assessments. Participants will undergo a multidimensional evaluation including clinical and neuropsychological tests, standardized motor tasks, and precise movement analysis using a sensor glove device called the Hand Test System (HTS). This device records objective motor data during tasks to characterize motor performance. The study includes two groups: patients with MCI and healthy controls. No experimental treatments are given; procedures are strictly for observation and research. Throughout the study, participants will complete assessments like finger tapping tests to measure motor skills alongside cognitive evaluations. Researchers will analyze how motor and cognitive reserves relate to clinical and neuropsychological status. The study plans to enroll about 200 participants aged 40 to 85 years and will help identify possible motor biomarkers for early cognitive decline. The study runs until July 2027 and involvement includes baseline motor and cognitive testing with no therapeutic interventions.
CONDITIONS
Brief Title
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Mild Cognitive Impairment (MCI) according to NIA-AA criteria for the MCI group
- Age between 40 and 85 years
- Native Italian speaker or sufficient proficiency in Italian to understand tests
- Signed informed consent by participant or legal representative
- Normal performance on neuropsychological screening for healthy subjects
- Signed informed consent for healthy subjects
You will not qualify if you...
- History of psychiatric or neurological disorders not related to MCI for MCI patients
- Use of psychotropic medications for MCI patients
- History of psychiatric or neurological disorders for healthy subjects
- Use of psychotropic medications for healthy subjects
- Disabling medical conditions affecting motor function for healthy subjects
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single assessment
Participants undergo clinical and neuropsychological evaluations, standardized motor tasks, and quantitative kinematic movement analysis using a sensor glove device to assess motor reserve and motor performance.
1 visit (in-person)
Duration - Up to study completion
Participants are observed to analyze the relationship between motor performance, cognitive reserve, and clinical status over time.
Visits as scheduled for observational follow-up
Trial Site Locations
Total: 1 location
1
Azienda Ospedaliera "Renato Dulbecco"
Catanzaro, Catanzaro, Italy, 88100
Actively Recruiting
Research Team
D
Domenico co Bosco, Medical Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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