Prediction of Post-stroke Cognitive Decline and Dementia: Impact of Cognitive Reserve and Post-stroke Life Style

What this Trial Is About

Researchers are studying how cognitive abilities change after a first-ever anterior circulation ischemic stroke. The goal is to create a model that predicts individual differences in how stroke affects cognition over time. This observational study is conducted over six years, with patient recruitment during the first three years, and focuses on understanding the impact of cognitive reserve and lifestyle after stroke. Patients are assessed at several stages: during the acute stroke phase (within 0-10 days after stroke), the sub-acute phase (3 months post-stroke), and the chronic phase (12 months and 3 years post-stroke). At each time point, comprehensive neuropsychological tests are performed alongside evaluations of clinical and functional status. Researchers also measure factors related to cognitive reserve and the patients' physical activity after stroke. Participants undergo detailed cognitive and functional assessments at each visit, including evaluations at 3 months, 12 months, and 36 months post-stroke. The main outcomes include the number of participants experiencing delayed cognitive or functional decline at these time points. The study also tracks cognitive impairment shortly after stroke and over the following years. The research accounts for challenges like participant dropout and mortality, aiming to provide a robust understanding of post-stroke cognitive trajectories.

Post-stroke Cognitive Impairment