Actively Recruiting
Prenatal Programming of Childhood Obesity and Cardio Metabolic Disorders - Role of Maternal Obesity, Pregnancy Complications, and Maternal-fetal Metabolome
Led by Helsinki University Central Hospital · Updated on 2024-12-10
750
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
H
Helsinki University Central Hospital
Lead Sponsor
U
University of Helsinki
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a follow-up study on mother-child pairs originally enrolled in two Finnish pregnancy cohort and prevention studies, PREDO and RADIEL. This research aims to investigate how maternal overweight, obesity, hypertensive disorders during pregnancy, and gestational diabetes relate to the child's birth outcomes and later overweight, obesity, and cardiometabolic health during childhood and adolescence. The study extends the follow-up period to include the children aged 11 to 17 years and assesses various health factors. The study includes detailed measurements of body weight, height, body fat percentage, blood pressure, and pulse among the children and their mothers. Children will undergo physical assessments such as Tanner staging, bioimpedance for body fat, and pulse wave velocity tests. Questionnaires will gather information on psychological development, diet, physical activity, and sleep. A subset of children will use continuous glucose monitoring devices. Mothers will also have health assessments, including blood tests, DNA sampling, and questionnaires on lifestyle and psychological health. Data from national registries and medical records will complement these measures. Participants will attend study visits where a variety of tests and questionnaires will be completed, including blood samples, metabolic and epigenetic analyses, and physical activity monitoring. Researchers will measure body fat percentage as the primary outcome, with secondary outcomes including blood pressure, body mass index, pulse wave velocity, and glucose monitoring data. The follow-up aims to provide insights into the long-term effects of maternal health during pregnancy on adolescent cardiometabolic outcomes, with data collection planned through 2024 and study completion expected by 2026.
CONDITIONS
Brief Title
Prenatal Programming of Childhood Obesity and Cardio Metabolic Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mothers who originally participated in the PREDO or RADIEL pregnancy studies during pregnancy and delivery
- Children aged 11 to 17 years born from the index pregnancy
You will not qualify if you...
- None listed in the study documentation or criteria provided in this trial data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From 11 to 17 years after pregnancy
Participants who originally took part in earlier pregnancy studies are followed up during adolescence to assess body composition, cardiovascular and metabolic health, and lifestyle factors.
1 follow-up visit with comprehensive assessments including physical measurements, questionnaires, blood samples, and activity monitoring; subpopulation may have additional 10 days of glucose monitoring
Trial Site Locations
Total: 1 location
1
Saila Koivusalo
Helsinki, Finland, 00290
Actively Recruiting
Research Team
S
Saila B Koivusalo, prof
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here