Post-polypectomy colorectal bleeding: current strategies and the way forward.
Nilanga Nishad, Mo Hameed Thoufeeq
https://pubmed.ncbi.nlm.nih.gov/39722137Actively Recruiting
Age: 18Years +
All Genders
ID07007598
Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants: a Retrospective Single Center Propensity Score Analysis
Led by Helios Kliniken Schwerin · Updated on 2025-06-18
10000
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
H
Helios Kliniken Schwerin
Lead Sponsor
M
Medical School Hamburg
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study focuses on adults who have undergone colorectal polypectomy and subsequently restarted anticoagulant therapy (excluding acetylsalicylic acid). Researchers aim to find out if applying clips to close the mucosal defect after polypectomy can prevent bleeding in these patients. The study uses a large patient registry from a single center to compare those who received preventive clipping with those who did not. The intervention under evaluation is the endoscopic application of a hemostatic clip after colorectal polypectomy to close the mucosal defect. Participants are grouped based on whether they received at least one prophylactic clip or no clip before restarting anticoagulants. The study is retrospective and observational, analyzing data from over 10,000 colonoscopies to investigate bleeding outcomes. Participants' records are reviewed to assess colorectal bleeding within 30 days after polypectomy. Researchers examine post-procedure outcomes related to bleeding events, considering factors such as polyp size and anticoagulant use. The study does not involve active treatment but monitors and analyzes past patient data to answer its main question about the effectiveness of clips in preventing bleeding after restarting anticoagulants.
CONDITIONS
Brief Title
Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult who has received a colonoscopy with endoscopic colorectal polypectomy
- Patient who has received at least one anticoagulant after polypectomy
You will not qualify if you...
- Endoscopic polypectomy combined with closure of the mucosal defect by a suturing device or full thickness resection device
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Day of polypectomy
Participants undergo colorectal polypectomy with or without prophylactic clipping to close the mucosal defect after the procedure.
1 procedure visit (in-person)
Monitoring
Duration - Up to 30 days after colorectal endoscopic polypectomy
Participants who have received restarted anticoagulants after polypectomy are observed for post-polypectomy colorectal bleeding.
Follow-up visits as per routine care
Trial Site Locations
Total: 1 location
1
Helios Kliniken Schwerin
Schwerin, Mecklenburg-Vorpommern, Germany, 19055
Actively Recruiting
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Research Team
D
Daniel Schmitz, Dr. med.
M
Martin Kliment
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Monika Ferlitsch, Cesare Hassan, Raf Bisschops...
https://pubmed.ncbi.nlm.nih.gov/38670139