Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial

What this Trial Is About

This research aims to compare the effectiveness of probiotic-based mouthwashes and ethyl lauroyl arginate-containing mouthwashes in reducing the amount of Streptococcus mutans bacteria, dental plaque buildup, and changes in saliva pH among Egyptian schoolchildren aged 6 to 12 years. Dental caries is a common chronic infectious disease in this population, with S. mutans playing a key role in enamel damage and plaque formation. Ethyl lauroyl arginate is known for its strong antibacterial effects and ability to reduce biofilm while preserving the balance of the oral microbiome. Participants will be randomly assigned to one of three groups: one group will use a probiotic mouthwash by rinsing 5 ml twice daily for 30 seconds over 28 days; a second group will use an ethyl lauroyl arginate mouthwash with the same dosing and duration; the third group will receive professional dental cleaning (scaling and polishing) at the start and then use only regular toothpaste twice daily without any additional mouthwash for 28 days. During the study, children will be monitored for changes in S. mutans levels, dental plaque accumulation, and salivary pH after 28 days of treatment. Researchers will measure these outcomes to evaluate how each treatment affects oral health. The trial includes baseline professional cleaning for one group, and all participants will be followed for the full 28-day period to assess the impact of the interventions on their oral bacteria and plaque levels.

Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children